Evidence map›Paper›PMID 41757918›Full record

ArticleInfection and immunity2026

Complex I preserves mitochondrial polarization during infection of human macrophages by secretion-competent bacteria.

Francisco-Javier Garcia-Rodriguez, Paula Martinez-Oca, Carmen Buchrieser, Pedro Escoll

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francisco-Javier Garcia-Rodriguez *Institut Pasteur, Université Paris Cité, Biologie des Bactéries Intracellulaires, Département de Microbiologie, Paris, France.ORCID 0000-0001-9933-1990
Paula Martinez-Oca *Institut Pasteur, Université Paris Cité, Biologie des Bactéries Intracellulaires, Département de Microbiologie, Paris, France.ORCID 0000-0003-0377-1401
Carmen BuchrieserInstitut Pasteur, Université Paris Cité, Biologie des Bactéries Intracellulaires, Département de Microbiologie, Paris, France.ORCID 0000-0003-3477-9190
Pedro EscollInstitut Pasteur, Université Paris Cité, Biologie des Bactéries Intracellulaires, Département de Microbiologie, Paris, France.ORCID 0000-0002-5933-094X

Funding

Agence Nationale de la Recherche ANR-10-LABX-62Agence Nationale de la Recherche ANR-21-CE15-0038-01Fondation pour la Recherche Médicale EQU202503020066Institut Pasteur PTR-651
6 · The paper itself

Abstract

Intracellular bacteria remodel host bioenergetics and modulate mitochondrial membrane potential (Δψm). However, how individual electron transport chain (ETC) components sustain Δψm during infection of primary human macrophages remains unclear. Here, we combined extracellular flux analysis with single-cell live imaging to understand how the ETC functions in human monocyte-derived macrophages during infection with

Indexed as

Electron Transport Complex ILegionella pneumophilaMacrophagesMitochondriaSalmonella typhimuriumHumansMembrane Potential, MitochondrialType IV Secretion SystemsElectron Transport Complex IType IV Secretion Systemselectron transport chainLegionella pneumophilamacrophagesmitochondriaSalmonella Typhimuriumvirulence

Identifiers

PMID41757918
PMCPMC13081716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.