ArticleJBRA assisted reproduction2026
The Beneficial Effects of Hesperidin and Exercise on the Histology and Biochemical Parameters of Surgically Induced Endometriosis in a Rabbit Model.
Article in JBRA assisted reproduction, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveEndometriosis is a gynecological disorder marked by the formation of endometrial tissue (gland and stroma) outside the uterine cavity. Macrophages, erythrocytes, and apoptotic endometrial tissue transplant into the peritoneal cavity, free radicals, and oxidative stress play a vital role in endometriosis. This study focused on unraveling the combinatorial effect of treadmill exercise with hesperidin (HESP, a citrus flavonoid) on histoarchitecture and biochemical [reactive oxygen species (ROS), nitric oxide (NO), total thiol (T-SH), glutathione (GSH), TBARS levels, catalase, glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione-s-transferase (GST), and monoamine oxidase activities] molecules in endometrial tissue of female rabbits.
methodsThe rabbits underwent surgery by resecting one uterine horn, isolating the endometrium, and fixing the tissue segment to the pelvic peritoneum, and they were distributed into 5 groups (n = 6). Group 1: normal control (NC) Group 2: untreated endometriotic rabbits (ENDO); Group 3: HESP-treated endometriotic rabbits (eNDO + HESP); Group 4: exercised endometriotic rabbits (ENDO + EXER); Group 5: exercised endometriotic rabbits administered with HESP (ENDO + HESP + EXER).
resultsThe results revealed that antioxidant enzyme activities and non-antioxidant molecules were reduced in untreated endometriotic rabbits compared to NC. However, there was a significant increase in antioxidant status in exercised endometriotic rabbits treated with hesperidin.
conclusionsThis finding revealed that combining physical exercise with the consumption of hesperidin-rich fruits can be explored to alleviate oxidative stress, a major risk factor in endometriosis.
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