ArticleJournal of global health2026
C-reactive protein predicts respiratory failure in chronic obstructive pulmonary disease: a cohort analysis from the UK Biobank.
Article in Journal of global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Respiratory failure (RF) is the leading cause of death in chronic obstructive pulmonary disease (COPD), yet reliable biomarkers for early risk stratification remain unclear. Circulating C-reactive protein (CRP) reflects systemic inflammation, but its prognostic value for incident RF in COPD is controversial. Methods: A total of 38 933 patients from the UK Biobank with the ratio of Forced Expiratory Volume in 1 second to Forced Vital Capacity (FEV Results: Kaplan-Meier curves showed statistically significant differences in RF across all subgroups throughout the entire follow-up period. Additionally, significant differences were observed between groups concerning all-cause mortality and COPD-induced mortality as well. The Cox proportional hazards model demonstrated a clear dose-response relationship between CRP concentration and RF, even after adjustment for several clinical covariates and systemic inflammation index. Conclusions: Serum CRP concentration may forecast a high risk of incident RF in patients with COPD, indicating further research on the threshold.
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