ReviewHippocampus2026
Non-Canonical Subiculum Circuit Organization and Function.
Review in Hippocampus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.bioRxiv : the preprint server for biology · 2026Article
- Article
- Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subiculum is highly interconnected with the hippocampus, sub-regions of the thalamus, and the entorhinal and retrosplenial cortices. Together, these regions form a distributed network that plays critical roles in spatial cognition and learning and memory. Despite recent discoveries detailing subiculum's circuitry and neural dynamics, a unique role for subiculum in this system has yet to be determined. Traditionally, the subiculum has been considered the "fourth leg" and output region of the trisynaptic pathway. However, recent evidence highlights the subiculum as a site of integration, receiving and redistributing outputs from the hippocampus, anterior thalamus, retrosplenial cortex, and entorhinal cortex. We review how these afferents may explain the diverse forms of spatial and directional tuning observed in the subiculum, including location coding, boundary-related signals, axis of travel, and head orientation. We also discuss more recently identified "non-canonical" connections that suggest additional roles for the subiculum in refining hippocampal processing. Together, these findings call for a reconceptualization of the subiculum's role in spatial cognition, memory, and integration across thalamic, cortical, and hippocampal networks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.