Evidence map›Paper›PMID 41757709›Full record

ArticleMolecular pain

Study on the role and mechanism of the IL-10-IRF-8 signaling pathway in bone marrow mesenchymal stem cell therapy for pain in CCD rats.

Yican Yang, Mutong Wang, Shuai Guo, Yan Feng, Yang Zhang, Shouwei Yue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yican YangRehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.ORCID 0009-0008-9576-9125
Mutong WangSchool of Nursing and Rehabilitation, Shandong University, Jinan, China.
Shuai GuoRehabilitation Center, Qilu Hospital of Shandong University, Jinan, China.
Yan FengDepartment of Rehabilitation Medicine, Weihai Wendeng District Integrated Traditional Chinese and Western Medicine Hospital, Weihai, China.
Yang ZhangRehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.
Shouwei YueRehabilitation Center, Qilu Hospital of Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the analgesic effects and mechanisms of BMSCs-IL-10 PATIENTS AND

methodsAfter CCD surgery, rats were administered intrathecal injections of PBS, BMSCs, BMSCs-IL-10

resultsCompared with the CCD+PBS group, intrathecal injection of both BMSCs and BMSCs-IL-10

conclusionIL-10 is a key cytokine mediating the analgesic effects of BMSCs. Transplantation of BMSCs-IL-10

Indexed as

Interferon Regulatory FactorsInterleukin-10Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationPainSignal TransductionAnimalsBone Marrow CellsInflammationInterferon Regulatory Factor-8MaleMicrogliaNeuralgiaRatsRats, Sprague-DawleyInterferon Regulatory Factor-8Interferon Regulatory FactorsInterleukin-10Bone marrow mesenchymal stem cellschronic compression of the dorsal root ganglionInterferon regulatory factor 8Interleukin-10neuropathic pain

Identifiers

PMID41757709
PMCPMC13039620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.