Evidence map›Paper›PMID 41757672›Full record

Observational studyJournal of diabetes investigation2026

Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study.

An-Yu Cheng, Chin-Chou Huang, Hsin-Bang Leu, Wei-Hsian Yin, Wei-Kung Tseng, Yen-Wen Wu, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang and 2 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

An-Yu ChengSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-3223-6643
Chin-Chou HuangSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-4217-8734
Hsin-Bang LeuCardiovascular Center, Taipei Veterans General Hospital, Taipei, Taiwan.
Wei-Hsian YinDivision of Cardiology, Heart Center, Cheng-Hsin General Hospital, Taipei, Taiwan.
Wei-Kung TsengDepartment of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung, Taiwan.
Yen-Wen WuCardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0003-1520-1166
Tsung-Hsien LinDivision of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan.
Hung-I YehSchool of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.
Kuan-Cheng ChangDivision of Cardiology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.ORCID https://orcid.org/0000-0001-6476-9896
Ji-Hung WangDepartment of Cardiology, Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan.
Chau-Chung WuDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Jaw-Wen ChenInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

National Science and Technology Council NSTC111-2314-B-A49A-509-MY3Taipei Veterans General Hospital V113C-032Taipei Veterans General Hospital V114C-005Taipei Veterans General Hospital V115C-046Taipei Veterans General Hospital VGHUST115-G1-8-1
6 · The paper itself

Abstract

AIMS/

introductionDiabetes mellitus significantly contributes to renal complications, especially in patients with coronary artery disease (CAD). Effective glycemic control is important; however, the ideal hemoglobin A1c (HbA1c) targets for this population remain uncertain. This observational cohort study aimed to identify appropriate HbA1c targets for patients with diabetes and chronic coronary syndrome. MATERIALS AND

methodsThis study included 1,223 patients with chronic coronary syndrome, which were identified from a multicenter cohort registry study. Among them, there were 698 patients with diabetes. Patients were categorized based on their diabetes status and HbA1c levels. The primary outcome was the incidence of minor and major renal events, defined as a decline in the estimated glomerular filtration rate (eGFR) of more than 25% and 50%. Cox proportional hazards regression models were employed to assess the impact of glycemic control on renal function.

resultsOver a mean follow-up of 3.2 ± 2.0 years, the highest incidences of minor renal events were noted in the group with diabetes and HbA1c ≥ 7.5% (25.1%), followed by diabetes and HbA1c < 6.5% (21.2%). Compared to the group without diabetes, the adjusted hazard ratios (95% confidence intervals) for minor renal events in the groups with diabetes and HbA1c ≥ 7.5%, HbA1c 7.0-7.4%, HbA1c 6.5-6.9%, and HbA1c < 6.5% were 3.06 (2.08-4.50), 1.75 (1.08-2.84), 1.32 (0.81-2.23), and 2.59 (1.58-4.24), respectively.

conclusionsAchieving HbA1c of 6.5 to 6.9% is associated with a reduced risk of renal complications in patients with diabetes and chronic coronary syndrome.

Indexed as

Coronary Artery DiseaseGlycemic ControlAgedBlood GlucoseCohort StudiesFemaleFollow-Up StudiesGlomerular Filtration RateGlycated HemoglobinHumansIncidenceMaleMiddle AgedBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanChronic coronary syndromeEstimated glomerular filtration rateHemoglobin A1c

Identifiers

PMID41757672
PMCPMC13137279

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.