ArticleMedical physics2026
A novel system for micron-scale analysis of energy deposition and response to low-dose radiation.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMicrometer-scale evaluation of energy deposition is important for radiation protection and therapy as well as for advancing knowledge of responses to radiation in materials and biological systems. Due to the stochastic nature of radiation interactions, there is significant variation in energy deposition in micrometer-sized targets, especially at low doses. This variability underscores the need for a framework for microdosimetry, particularly in low-dose scenarios. PURPOSE: The goal of this work is to develop a novel system for micron-scale characterization of energy deposition and response to radiation that is applicable at low doses, using a combination of Monte Carlo (MC) simulations and experimental techniques.
methodsEBT3 radiochromic film samples are irradiated to absorbed doses of 0.003-0.5 Gy using the 6-MV beam from a clinical linear accelerator. To quantify energy deposition, MC simulations of the experimental irradiations are conducted to evaluate specific energy deposited within micron-scale voxels in the active layer of the film. To investigate the dose response of the film, the following two methods are employed: (i) flatbed scanner measurement of changes in optical density (OD) of the film, and (ii) Raman spectroscopy (RS) to measure response intensity across doses with micron-scale resolution. Experimental film responses are compared to predictions from the microdosimetric one-hit model.
resultsSpecific energy distributions obtained from MC simulations show large variation in energy deposition at low doses and within small targets; the "microdosimetric spread" (relative standard deviation) is significantly higher (
conclusionThis study provides first results of a system that combines simulations with experimental techniques to investigate radiation response in micron-scale targets, with a focus on low-dose radiation exposure. The system shows promise in enabling future investigations of energy deposition within small volumes at low doses, where biological responses may be heterogeneous as some cells may receive high energy deposits and incur damage, while others may experience minimal or no deposition.
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