Evidence map›Paper›PMID 41757294›Full record

ArticleJournal of orthopaedic translation2026

Endothelin-1/endothelin B receptor signalling mediates Prx1

Zhou Zou, Weiyuan Gong, Xuan Lu, Yuqi Zhang, Manting Au, Junxin Lin, Hongwei Ouyang, Guozhi Xiao, Bin Tang, Chunyi Wen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhou ZouDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Weiyuan GongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Xuan LuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Yuqi ZhangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Manting AuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Junxin LinSchool of Medicine, Taizhou University, Taizhou, Zhejiang, China.
Hongwei OuyangZhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Guozhi XiaoDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Shenzhen, Guangdong, China.
Bin TangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Chunyi WenDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stem cells residing in the perivascular niche are critical for skeletal homeostasis. Vascular endothelin-1 (ET-1) controls stem cell fate in development, but its role in the exhaustion of skeletal stem cells (SSCs) and subsequent bone degeneration in osteoporosis remains poorly understood. This study aimed to determine whether ET-1 signalling drives SSCs senescence and to elucidate the underlying mechanisms. Methods: We utilised a combination of human single-cell RNA sequencing datasets, murine models of ageing and ovariectomy (OVX), and an endothelial-specific ET-1 overexpression transgenic (TET-1) mouse model. Results: In aged and OVX mice, ET Conclusion: This study identified the ET-1/ET The translational potential of this article: This study positioned ET

Indexed as

AgeingCellular senescenceEndothelin-1Endothelin type B receptorOsteoporosisSkeletal stem cells

Identifiers

PMID41757294
PMCPMC12933462

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.