ArticleFrontiers in endocrinology2026
Regional brain serotonergic activity as an indicator of chronic stress and compromised welfare in fish.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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11 authors.
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Abstract
Background: Chronic stress in aquaculture poses major challenges to fish welfare, health, and productivity. Detecting compromised welfare early requires validated biomarkers that link operational welfare indicators (OWIs) to underlying neuroendocrine states, including allostatic load and stress coping capacity. The central serotonergic system is a promising candidate for such validation, given its conserved role in stress regulation across vertebrates. Methods: We sampled 40 Atlantic salmon ( Results: Brain stem 5-HT concentration and turnover were consistently associated with welfare-related indicators and loaded strongly with these variables in multivariate space, indicating sensitivity to cumulative stress and compromised welfare. In contrast, telencephalic 5-HT turnover aligned primarily with acute stress metrics rather than welfare state. MANOVA and Conclusion: Our findings demonstrate a clear regional dissociation in central 5-HTergic stress processing in Atlantic salmon: brain stem 5-HT activity reflects chronic stress burden and welfare state, whereas telencephalic 5-HT turnover reflects acute stress reactivity conditional on baseline welfare. These results support the use of region-specific 5-HTergic measures as biologically grounded markers distinguishing chronic welfare compromise from functional acute stress responses in aquaculture, while emphasizing caution when interpreting acute stress reactivity in chronically stressed individuals.
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