Evidence map›Paper›PMID 41757171›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Short tandem repeats significantly contribute to the genetic architecture of metabolic and sensory age-related hearing loss phenotypes.

Samah Ahmed, Kenneth I Vaden, Judy R Dubno, Galen E B Wright, Britt I Drögemöller

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samah AhmedDepartment of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Kenneth I VadenDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Judy R DubnoDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Galen E B WrightDepartment of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Britt I DrögemöllerDepartment of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Funding

SPEECH UNDERSTANDING IN REALISTIC ENVIRONMENTSP50DC000422 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 1989 to 2025
$45.3M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
RENOVATION TO SUPPORT SENSORY NEUROSCIENCE RESEARCHC06RR014516 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 1999 to 1999
–
NCATS NIH HHS UL1 TR001450NCRR NIH HHS C06 RR014516NIDCD NIH HHS P50 DC000422
6 · The paper itself

Abstract

Age-related hearing loss (ARHL) is a progressive, bilateral decline in hearing ability that affects one in four individuals over 60 years of age worldwide. While previous genome-wide association studies (GWAS) have identified distinct single-nucleotide variants (SNVs) associated with metabolic and sensory ARHL phenotypes, the contribution of short tandem repeats (STRs) - a neglected yet important class of genetic variants - remains poorly understood. To address this gap, TRTools was used to impute STRs from a high quality, sequencing-derived SNV-STR reference panel to investigate the association between STRs and metabolic and sensory estimates. Heritability analyses revealed that while STRs contribute to estimates of both ARHL components, this class of variation plays a more important role in metabolic hearing loss (6%), which typically increases with age, compared to sensory hearing loss (4%). Further, the inclusion of this class of variant into GWAS analyses uncovered an association between a haplotype consisting of two missense variants (rs7714670 and rs6453022) and an intronic STR (chr5:73778077:A

Indexed as

age-related hearing loss (ARHL)audiogramsCanadian Longitudinal Study on Aging (CLSA)genome-wide association analyses (GWAS)short tandem repeats (STRs)

Identifiers

PMID41757171
PMCPMC12934861

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.