ArticleEuroasian journal of hepato-gastroenterology
Prognostic Value of Neutrophil-to-lymphocyte Ratio in Patients with Acute-on-chronic Liver Failure in Comparison with Standard Scores: A Cross-sectional Observational Study from a Tertiary Care Hospital in South India.
Article in Euroasian journal of hepato-gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/aims: Acute-on-chronic liver failure (ACLF) is a clinical entity that denotes deteriorates liver function in patients with underlying liver disease. Most studies indicate that the neutrophil-to-lymphocyte ratio (NLR). Neutrophil-to-lymphocyte ratio is a valuable prognostic marker in patients with ACLF. This study aims to assess the role of NLR ratio and evaluate the accuracy of NLR as a prognostic marker in ACLF and to compare the NLR with other standard scores. Materials and methods: This study was conducted among patients with ACLF. Neutrophil-to-lymphocyte ratio was calculated by dividing the neutrophil count by the lymphocyte count. Neutrophil-to-lymphocyte ratio was compared with AARC score, CLIF-C ACLF score, MELD-Na score, and Child-Pugh classification as a prognostic marker in ACLF. Results: A total of 109 patients were included, and the majority, (94.5%), were men with a mean age of 45 ± 11.2 years. The NLR emerged as a valuable prognostic marker. Patients with NLR >5 demonstrated significantly higher levels of C-reactive protein (CRP), alanine aminotransferase (ALT), and CLIF-C ACLF scores, reflecting greater systemic inflammation and hepatic injury. These patients also had a higher in-hospital mortality (53.1% and 26.7%, Conclusion: With increased NLR suggesting a higher probability of death, the study emphasizes the importance of NLR as a useful prognostic biomarker in patients with ACLF. Clinical significance: Neutrophil-to-lymphocyte ratio is a prognostic marker to identify the risk of mortality in ACLF patients and helps in timely clinical decisions. Elevated NLR can help clinicians in prioritizing patients for liver transplantation. How to cite this article: Kumar BS, Krishnamoorthy P, Arumaikani S,
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