Evidence map›Paper›PMID 41757125›Full record

ArticlebioRxiv : the preprint server for biology2026

Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.

Alenka Hafner, Hardik Kundariya, Robersy Sanchez, Akshay U Nair, Sally A Mackenzie

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alenka HafnerDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, 16801, United States.ORCID 0000-0003-4262-9176
Hardik KundariyaDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, 16801, United States.ORCID 0000-0002-4065-3888
Robersy SanchezDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, 16801, United States.ORCID 0000-0002-5246-1453
Akshay U NairDepartment of Biology, Indian Institute of Science Education and Research (IISER), Tirupati, 517507, Andhra Pradesh, India.
Sally A MackenzieDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, 16801, United States.ORCID 0000-0003-2077-5607

Funding

Modeling stress-induced, de novo epiallele architecture in the model Arabidopsis as a tractable entrypointR01GM134056 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MACKENZIE, SALLY A · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM134056
6 · The paper itself

Abstract

The role of intragenic cytosine methylation in shaping phenotypes has been contentious. Recent studies show association between stress and alternative splicing of transcripts, but without functional genome-wide or single-position analysis. We utilized the

Identifiers

PMID41757125
PMCPMC12934970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.