Evidence map›Paper›PMID 41757113›Full record

ArticlebioRxiv : the preprint server for biology2026

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.

Jean R P Gatdula, Isabel C Orbe, Samantha G Tolton, Linnea M Saunders, Janelle S Vultaggio, Robert C C Mercer, Jason C Bartz, Glenn C Telling, Hasier Eraña, Joaquín Castilla and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jean R P GatdulaDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0000-0003-4322-3880
Isabel C OrbeDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0000-0003-4467-6590
Samantha G ToltonDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0009-0000-2993-1368
Linnea M SaundersDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.
Janelle S VultaggioDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.
Robert C C MercerDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0000-0001-6029-511X
Jason C BartzDepartment of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, Nebraska 68178, United States of America.ORCID 0000-0003-4081-7886
Glenn C TellingDepartment of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America.
Hasier ErañaCenter for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
Joaquín CastillaCenter for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
David A HarrisDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLAUDIO SOTO · 2008 to 2026
$36.1M
Mechanisms of Prion Protein ToxicityR01NS065244 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2010 to 2025
$8.9M
Maximizing research success in studies of naturally-occurring prion diseasesR35NS132226 · NINDS · COLORADO STATE UNIVERSITY · PI Glenn C Telling · 2023 to 2026
$3.1M
Contributions of prion strains and substrains to prion zoonotic potential and evolutionR01NS133050 · NINDS · CREIGHTON UNIVERSITY · PI Jason C Bartz · 2023 to 2026
$2.2M
NIAID NIH HHS P01 AI077774NINDS NIH HHS R01 NS065244NINDS NIH HHS R01 NS133050NINDS NIH HHS R35 NS132226
6 · The paper itself

Abstract

Prion diseases are fatal neurodegenerative disorders with no approved therapies that halt or reverse disease progression. Given that cellular prion protein (PrP

Identifiers

PMID41757113
PMCPMC12934677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.