ArticlebioRxiv : the preprint server for biology2026
Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.
Jean R P Gatdula, Isabel C Orbe, Samantha G Tolton, Linnea M Saunders, Janelle S Vultaggio, Robert C C Mercer, Jason C Bartz, Glenn C Telling, Hasier Eraña, Joaquín Castilla and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Jean R P GatdulaDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0000-0003-4322-3880 Isabel C OrbeDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0000-0003-4467-6590 Samantha G ToltonDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0009-0000-2993-1368 Linnea M SaundersDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.
Janelle S VultaggioDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.
Robert C C MercerDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.ORCID 0000-0001-6029-511X Jason C BartzDepartment of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, Nebraska 68178, United States of America.ORCID 0000-0003-4081-7886 Glenn C TellingDepartment of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America.
Hasier ErañaCenter for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
Joaquín CastillaCenter for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
David A HarrisDepartment of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States of America.
Funding
Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLAUDIO SOTO · 2008 to 2026
$36.1MMechanisms of Prion Protein ToxicityR01NS065244 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2010 to 2025
$8.9MMaximizing research success in studies of naturally-occurring prion diseasesR35NS132226 · NINDS · COLORADO STATE UNIVERSITY · PI Glenn C Telling · 2023 to 2026
$3.1MContributions of prion strains and substrains to prion zoonotic potential and evolutionR01NS133050 · NINDS · CREIGHTON UNIVERSITY · PI Jason C Bartz · 2023 to 2026
$2.2MNIAID NIH HHS P01 AI077774NINDS NIH HHS R01 NS065244NINDS NIH HHS R01 NS133050NINDS NIH HHS R35 NS132226
6 · The paper itselfAbstract
Prion diseases are fatal neurodegenerative disorders with no approved therapies that halt or reverse disease progression. Given that cellular prion protein (PrP
Identifiers
PMID41757113
PMCPMC12934677
What OpenQuestion holds
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