Evidence map›Paper›PMID 41757095›Full record

ArticlebioRxiv : the preprint server for biology2026

Ecological and evolutionary dynamics of the oral microbiome across childhood.

Fang Wang, Andrew J Holmes, Gina V Browne, Xuzhen He, Michelle R Bockmann, Kylie M Davis, Toby E Hughes, Christina J Adler

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fang WangSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.ORCID 0000-0003-3505-524X
Andrew J HolmesCharles Perkins Centre, The University of Sydney, Sydney, Australia.ORCID 0000-0002-7406-4387
Gina V BrowneSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Xuzhen HeSchool of Civil and Environmental Engineering, University of Technology Sydney, Sydney, Australia.ORCID 0000-0001-5336-3663
Michelle R BockmannSchool of Dentistry, Adelaide University, Adelaide, Australia.
Kylie M DavisSchool of Dentistry, Adelaide University, Adelaide, Australia.
Toby E HughesSchool of Dentistry, Adelaide University, Adelaide, Australia.ORCID 0000-0001-8668-7744
Christina J AdlerSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.ORCID 0000-0002-4731-5291

Funding

Reconstructing early life environmental exposures using tooth biomarkers and their influence on the trajectory of the oral microbiome and oral health in childhoodR01DE029838 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ADLER, CHRISTINA JANE, PETRICK, LAUREN · 2020 to 2024
$3.3M
NIDCR NIH HHS R01 DE029838
6 · The paper itself

Abstract

Childhood represents a critical period for oral microbiome development, yet evolutionary trajectories and the relative roles of host and environment remain unclear. Using a large longitudinal metagenomic dataset of 920 samples from a twin cohort spanning the first decade of life, we characterised microbial shifts and population dynamics of key bacterial groups. Microbiome diversity was initially reduced and highly heterogeneous and became increasingly complex and convergent with age. Microbial community state was associated with developmental age, environment and in late childhood was surprisingly strongly associated with host genotype. Strain-level analyses revealed species-specific temporal patterns of genetic variation particularly within

Indexed as

genetic diversityhuman oral microbiomemetagenomicsmicrobial ecology

Identifiers

PMID41757095
PMCPMC12934632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.