Evidence map›Paper›PMID 41757091›Full record

ArticlebioRxiv : the preprint server for biology2026

A neofunctionalized flowering antagonist created an evolutionary contingency that channeled Solanaceae adaptation.

Hagai Shohat, Danielle Ciren, Andrea Arrones, Iacopo Gentile, Srividya Ramakrishnan, Anat Hendelman, Katharine M Jenike, Nicole L Brown, Jose Luna-Ramos, Michael J Passalacqua and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hagai ShohatCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0003-1195-7986
Danielle CirenSchool of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-1624-1808
Andrea ArronesCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0003-3926-0291
Iacopo GentileCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-3202-9129
Srividya RamakrishnanDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-8023-4752
Anat HendelmanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-6089-710X
Katharine M JenikeDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7276-8110
Nicole L BrownDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-1750-0699
Jose Luna-RamosInstituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Valencia, Spain.ORCID 0009-0000-3628-9238
Michael J PassalacquaSchool of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-6344-1175
James W SatterleeCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-0267-4944
Blaine FitzgeraldCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0009-0004-8503-4978
Virginia Baraja-FonsecaInstituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Valencia, Spain.ORCID 0000-0001-9072-4771
Gina M RobitailleCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-7654-5002
Brooke M SemanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0009-0002-0033-744X
Jesse GillisPhysiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-0936-9774
Joyce Van EckBoyce Thompson Institute, Ithaca, NY, USA.ORCID 0000-0002-8005-365X
Jaime ProhensInstituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Valencia, Spain.ORCID 0000-0003-1181-9065
Michael C SchatzDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-4118-4446
Zachary B LippmanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0001-7668-9025

Funding

Democratization of Data Analysis in Life Sciences Through GalaxyU24HG006620 · NHGRI · PENNSYLVANIA STATE UNIVERSITY, THE · PI Daniel James Blankenberg, Jeremy Goecks · 2021 to 2026
$9.8M
NHGRI NIH HHS U24 HG006620
6 · The paper itself

Abstract

Neofunctionalization is a rare fate of gene duplication, classically defined as the acquisition of novel functions that potentiate the emergence of new traits. Rather than evolving to function autonomously, neofunctionalized genes may also remain embedded within their ancestral regulatory networks, potentially reshaping the genetic trajectories through which phenotypic change occurs. Testing this hypothesis, we leveraged a pan-genetic platform comprising ten Solanaceae species and show that a paralog of the flowering hormone

Indexed as

contingencydomesticationfloweringgene-regulatory networkneofunctionalizationpan-geneticspan-genomicsparallel adaptationSolanaceae

Identifiers

PMID41757091
PMCPMC12934750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.