Evidence map›Paper›PMID 41757089›Full record

ArticlebioRxiv : the preprint server for biology2026

LINE-1 retrotransposition is a recurrent cause of

Jennifer A Karlow, Callan O'Connor, Radwa Sharaf, Dean C Pavlick, Andrej Savol, Christopher Darcy, Akshay Kakumanu, William Camara, Matthew Walsh, Tyler Janovitz and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jennifer A KarlowDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0001-5041-2669
Callan O'ConnorFoundation Medicine Inc., Boston, MA.
Radwa SharafFoundation Medicine Inc., Boston, MA.
Dean C PavlickFoundation Medicine Inc., Boston, MA.
Andrej SavolFoundation Medicine Inc., Boston, MA.
Christopher DarcyFoundation Medicine Inc., Boston, MA.
Akshay KakumanuFoundation Medicine Inc., Boston, MA.
William CamaraFoundation Medicine Inc., Boston, MA.
Matthew WalshFoundation Medicine Inc., Boston, MA.
Tyler JanovitzFoundation Medicine Inc., Boston, MA.
Michael J KelleyNational Oncology Program, Department of Veteran Affairs, Washington, DC.
Christine N SerwayDanaher Diagnostics, Washington DC.
Jerry MitchellFoundation Medicine Inc., Boston, MA.
Julia A ElvinFoundation Medicine Inc., Boston, MA.
Meagan MontesionFoundation Medicine Inc., Boston, MA.
Kathleen H BurnsDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0003-1620-3761
Garrett M FramptonFoundation Medicine Inc., Boston, MA.

Funding

Consequences of retrotransposition on genome integrityR01CA276112 · NCI · DANA-FARBER CANCER INST · PI KATHLEEN H BURNS, Alice Eunjung Lee · 2023 to 2026
$2.9M
Immunological consequences of LINE-1 expression in cancerR01CA289390 · NCI · GEORGE WASHINGTON UNIVERSITY · PI KATHLEEN H BURNS, Katherine B Chiappinelli · 2024 to 2026
$1.9M
Defining the genomic and biologic impact of LINE-1 activity in fallopian tube epithelial cellsR01CA299969 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KATHLEEN H BURNS, Bo R. RUEDA · 2025 to 2026
$1.5M
Single Molecule Detection of L1 Insertions and IntermediatesUG3NS132127 · NINDS · DANA-FARBER CANCER INST · PI BERNSTEIN, BRADLEY EVAN, BURNS, KATHLEEN H · 2023 to 2024
$879k
NCI NIH HHS R01 CA276112NCI NIH HHS R01 CA289390NCI NIH HHS R01 CA299969NINDS NIH HHS UG3 NS132127
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alternative splicingCancer geneticsdriver mutationinsertional mutagenesisoncogene activationretrotransposonsomatic mosaicism

Identifiers

PMID41757089
PMCPMC12934576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.