ArticlebioRxiv : the preprint server for biology2026
Temperature effects on taste preferences are influenced by TRPM8.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Taste perception is influenced by stimulus and oral temperature. Change in oral temperature modulates trigeminal neurons. Whether trigeminal thermal sensing interacts with taste is unknown. Here we studied temperature influences on mouse taste preferences and how they could change following silencing of TRPM8 (transient receptor potential melastatin 8) - a thermoreceptor supporting cool and warm temperature coding by trigeminal neurons. Female and male TRPM8 gene deficient and C57BL/6J (B6) control mice (n = 69) entered thermolickometry tests where they sampled taste solutions at cool (15°C) and warm (30°C) temperatures during brief-access (10-sec long) exposure trials, which capture oral sensory/tongue control of licking behavior. Taste solutions included innately avoided bitter quinine (0.03 and 0.3 mM) and preferred sugars (sucrose or glucose, 100 and 500 mM). Mice were respectively maintained under water restriction or water-replete conditions during quinine and sugar tests, which were conducted separately. Analyses revealed that 15°C enhanced, while 30°C reduced, licks to quinine in both B6 and TRPM8 deficient mice, which responded similarly (
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