Evidence map›Paper›PMID 41757083›Full record

ArticlebioRxiv : the preprint server for biology2026

Identification of 4,5,6,7-Tetrabromo-1

Alexander A Mestre, Yunju Oh, Jianli Wu, Denise Dunn, Yasaman Setayeshpour, Ssu-Yu Chen, Chao-Chieh Lin, C Skyler Cochrane, Pyeonghwa Jeong, Gibeom Nam and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexander A MestreDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0002-2963-1354
Yunju OhDepartment of Chemistry, Duke University, Durham, NC, 27708.ORCID 0009-0002-2786-0097
Jianli WuDepartment of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Denise DunnDepartment of Radiation Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.
Yasaman SetayeshpourDepartment of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0002-3420-8841
Ssu-Yu ChenDepartment of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0001-6144-5749
Chao-Chieh LinDepartment of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.
C Skyler CochraneDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0003-4156-2336
Pyeonghwa JeongDepartment of Chemistry, Duke University, Durham, NC, 27708.ORCID 0009-0000-3796-7627
Gibeom NamDepartment of Chemistry, Duke University, Durham, NC, 27708.ORCID 0009-0002-0587-2126
Chloe MarkeyDepartment of Biomedical Engineering, Duke University, Durham, NC, 27710, USA.ORCID 0009-0006-4176-3145
Daniel RekerDepartment of Biomedical Engineering, Duke University, Durham, NC, 27710, USA.ORCID 0000-0003-4789-7380
Scott R FloydDepartment of Radiation Oncology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0002-8067-2426
Jiyong HongDepartment of Chemistry, Duke University, Durham, NC, 27708.ORCID 0000-0002-5253-0949
Pei ZhouDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0002-7823-3416
Jen-Tsan ChiDepartment of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0003-3433-903X

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
Biochemical and functional investigation of the novel enzymatic activities of MESH1R01GM124062 · NIGMS · DUKE UNIVERSITY · PI CHI, JEN-TSAN ASHLEY, ZHOU, PEI · 2018 to 2021
$2.0M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Development of MESH1 inhibitors to treat ferroptosis-associated neurodegenerationR21AG077075 · NIA · DUKE UNIVERSITY · PI CHI, JEN-TSAN ASHLEY, HONG, JIYONG · 2022 to 2022
$428k
NIA NIH HHS R21 AG077075NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM124062NIH HHS S10 OD021527
6 · The paper itself

Abstract

Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation and contributes to diverse pathologies including ischemia-reperfusion injury and neurodegenerative disorders. Current ferroptosis inhibitors largely function as nonspecific radical-trapping antioxidants, limiting their clinical utility. We previously identified MESH1 as a key regulator of ferroptosis through its NADPH phosphatase activity. Here, we identify 4,5,6,7-tetrabromo-1

Indexed as

4,5,6,7-tetrabromo-1H-benzotriazoleFerroptosisHDDC3MESH1NADPHTBB

Identifiers

PMID41757083
PMCPMC12934728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.