In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
29 authors.
Sang Ho KwonLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-5328-0956 Boyi GuoDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-2950-2349 Cindy FangDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-7164-5461 Madhavi TippaniLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-6465-6418 Svitlana V BachLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-1134-9585 Ryan A MillerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-3477-7443 Sarah E MaguireLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0009-0005-2884-4787 Nicholas J EaglesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-9808-5254 Madeline R ValentineLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-6078-2794 Vijetha BalakundiDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.ORCID 0009-0003-5631-3006 Annie B NguyenLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-3842-6923 Uma M KaipaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-4931-1753 Heena R DivechaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-1959-0675 Jashandeep S LobanaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-4210-6052 Shizhong HanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-5114-6742 Nikolaos P DaskalakisDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.ORCID 0000-0003-1660-9112 Thomas M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-8746-3037 Leonardo Collado-TorresLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-2140-308X Stephanie C PageLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-1951-7398 Kristen R MaynardLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-0031-8468 Stephanie C HicksDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-7858-0231 Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-5237-0789 Funding
Laminar dissection of cortical human brain gene expression in neuropsychiatric disordersR01MH126393 · NIMH · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2021 to 2025
$3.9MIntegrative cellular deconvolution of human brain RNA sequencing dataR01MH123183 · NIMH · LIEBER INSTITUTE, INC. · PI HICKS, STEPHANIE CARINNE, MAYNARD, KRISTEN ROSE · 2020 to 2023
$2.3MComputational Methods for Emerging Spatially-resolved Transcriptomics with Multiple SamplesR35GM150671 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Stephanie Carinne Hicks · 2023 to 2026
$1.2MNIGMS NIH HHS R35 GM150671NIMH NIH HHS R01 MH123183NIMH NIH HHS R01 MH126393
6 · The paper itselfAbstract
The dorsolateral prefrontal cortex (dlPFC) controls many cognitive and emotional processes that are disrupted in schizophrenia (SCZ). However, the spatial location of molecular changes associated with SCZ within the dlPFC remains poorly characterized. dlPFC cell types are spatially organized across six layers into microcircuits that mediate dlPFC function. While SCZ has been linked to regionally-defined cell types, spatially-resolved transcriptomics (SRT) can more directly map molecular associations of disease. We integrated protein detection for perineuronal nets, neurons and vasculature with SRT to investigate how gene expression varies across different cellular microenvironments in the human dlPFC from neurotypical control (n=31) and SCZ (n=32) brain donors. We mapped transcriptional alterations in synaptic, neuroimmune and metabolic pathways to neuropil and glia-enriched domains including the white matter. Integrative analyses linked laminar alterations predominantly to non-neuronal populations, and
Indexed as
dorsolateral prefrontal cortexpostmortem human brainSchizophreniaspatially-resolved transcriptomics
Identifiers
PMID41757081
PMCPMC12934622
What OpenQuestion holds
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LicenceCC BY-NC
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