Evidence map›Paper›PMID 41757080›Full record

ArticlebioRxiv : the preprint server for biology2026

Environmental perturbation increases gene expression variability and unmasks genetic regulation for transcriptional robustness.

James Phipps-Tan, Saudat Alishayeva, Huiting Xu, Julien F Ayroles, Luisa F Pallares

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James Phipps-TanFriedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany.ORCID 0009-0004-2536-0114
Saudat AlishayevaFriedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany.
Huiting XuFriedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany.
Julien F AyrolesDepartment of Integrative Biology, UC Berkeley, Berkeley, 94720, CA, USA.ORCID 0000-0001-8729-0511
Luisa F PallaresFriedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany.ORCID 0000-0001-6547-1901

Funding

A path to personalized phenotypic prediction: unlocking the context-dependency of allelic effectsR35GM124881 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Julien Ayroles · 2017 to 2026
$3.7M
Improved methods for inference of genotype-specific response to environmental toxinsR01ES029929 · NIEHS · PRINCETON UNIVERSITY · PI AYROLES, JULIEN, CLARK, ANDREW G · 2019 to 2023
$3.6M
NIEHS NIH HHS R01 ES029929NIGMS NIH HHS R35 GM124881
6 · The paper itself

Abstract

Environmental perturbation reshapes phenotypes not only by shifting trait means but also by modulating phenotypic variability. Whether environmentally induced changes in variability -environmental robustness- are genetically regulated remains unclear. To address this question, we collected nearly 2,000 matched genomes and transcriptomes from an outbred population of

Indexed as

cryptic genetic variationexpression noisegenotype-by-environment interactionrobustnessvariance QTLveQTL

Identifiers

PMID41757080
PMCPMC12934938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.