Evidence map›Paper›PMID 41757052›Full record

ArticlebioRxiv : the preprint server for biology2026

Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at the

Luciana Bertholim-Nasciben, Liyong Wang, Wanying Xu, Aura Ramirez, Sofia Moura, Leina Lu, Xiaoxiao Liu, Farid Rajabli, Katrina Celis, Marla Gearing and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Luciana Bertholim-NascibenJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Liyong WangJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Wanying XuDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Aura RamirezJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Sofia MouraJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Leina LuDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Xiaoxiao LiuDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Farid RajabliJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Katrina CelisJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Marla GearingGoizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, 30322, USA.
David A BennettDepartment of Neurological Sciences, Rush University, Chicago, IL, USA.
Sandra WeintraubNorthwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Changiz GeulaNorthwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Theresa SchuckThe Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Karen NuytemansJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
William K ScottJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Derek M DykxhoornJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Juan I YoungJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Anthony J GriswoldJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.
Fulai JinDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Jeffery M VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.

Funding

Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, William S Bush · 2022 to 2026
$55.3M
Inclusion of sub-group of ASPREE samples into the ADSPU01AG066767 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CUCCARO, MICHAEL L, KUNKLE, BRIAN WILLIAM · 2020 to 2024
$21.9M
Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic AncestryR01AG070864 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Margaret A. Pericak-Vance, FARID RAJABLI · 2021 to 2026
$12.1M
Functional genomic studies in diverse populations to characterize risk loci for Alzheimer DiseaseU01AG072579 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DYKXHOORN, DEREK MICHAEL, GRISWOLD, ANTHONY JOHN · 2021 to 2025
$6.9M
Replication and Extension of ADSP Discoveries in African-AmericansU01AG052410 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEECHAM, GARY WAYNE, BYRD, GOLDIE S. · 2016 to 2020
$5.2M
Identifying Protective Genetic Variants for APOE4RF1AG059018 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VANCE, JEFFERY MARVIN · 2018 to 2018
$4.4M
The Origins of Alzheimer Disease in Individuals of African AncestryR56AG072547 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEECHAM, GARY WAYNE, BYRD, GOLDIE S. · 2021 to 2021
$3.0M
NIA NIH HHS R01 AG070864NIA NIH HHS R56 AG072547NIA NIH HHS RF1 AG059018NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG066767NIA NIH HHS U01 AG072579NIA NIH HHS U19 AG074865
6 · The paper itself

Abstract

Objective: Both the phosphatidylinositol binding clathrin assembly protein gene ( Methods: Hi-C data from the frontal cortex of eight AD patients, as well as inducible pluripotent stem cell-derived microglia and spheroids of AD and control patients were used. We applied 14 eHiCA baits each containing a GWAS SNP to identify the Results: The baits derived from the GWAS associated haplotype primarily interacted with the PICALM promoter and the large cis-regulatory elements cluster (CREe) lying upstream of the Interpretation: The

Identifiers

PMID41757052
PMCPMC12934636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.