Evidence map›Paper›PMID 41756954›Full record

ArticlebioRxiv : the preprint server for biology2026

SMCHD1 loss re-wires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells.

Zhijun Huang, Wei Cui, Adam Klaiss, Gerd P Pfeifer

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhijun HuangDepartment of Epigenetics, Van Andel Institute, Grand Rapids, Michigan, USA.
Wei CuiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, Michigan, USA.
Adam KlaissDepartment of Epigenetics, Van Andel Institute, Grand Rapids, Michigan, USA.
Gerd P PfeiferDepartment of Epigenetics, Van Andel Institute, Grand Rapids, Michigan, USA.

Funding

5-methylcytosine oxidation in development and diseaseR01AR079174 · NIAMS · VAN ANDEL RESEARCH INSTITUTE · PI PFEIFER, GERD P · 2021 to 2025
$2.1M
NIAMS NIH HHS R01 AR079174
6 · The paper itself

Abstract

Human SMCHD1 (Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1) is a chromatin architectural protein linked to heterochromatin repression. Loss of function mutations of SMCHD1 cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) through activation of the

Indexed as

3D chromatin structurechromatin accessibilityenhancer nexusepigenomeHiCMYOD1SMCHD1

Identifiers

PMID41756954
PMCPMC12934784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.