Evidence map›Paper›PMID 41756950›Full record

ArticlebioRxiv : the preprint server for biology2026

Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer.

Yansu Song, Yi Hao, Maria Latacz, Marta Cykowiak, Julia Kirylczuk, Xuebo Quan, Francesco Palomba, Songwei Ni, Linjie Liu, Jing Hu and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yansu SongThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yi HaoDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Maria LataczDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Marta CykowiakDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Julia KirylczukDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Xuebo QuanInstitute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Francesco PalombaLaboratory of Fluorescence Dynamics, The Henry Samueli School of Engineering, University of California, Irvine, CA, USA.
Songwei NiThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Linjie LiuThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jing HuZhengzhou Research Institute, Harbin Institute of Technology, Zhengzhou, China.
Bi ShiHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha, Hunan, China.
Ammon PoseyDepartment of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Qiaoli LiThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Haoran YuanDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jie SunThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Rohit PappuDepartment of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Michelle A DigmanLaboratory of Fluorescence Dynamics, The Henry Samueli School of Engineering, University of California, Irvine, CA, USA.
Kai HuangInstitute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Hao JiangThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
Zeiss 780 NLO High Sensitivity Multiphoton Microscopy SystemS10OD016446 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2013 to 2013
$600k
NCI NIH HHS P30 CA044579NIH HHS S10 OD016446
6 · The paper itself

Abstract

The pathological mechanisms and significance for the prevalent hotspot mutations in disordered protein regions are poorly understood. ASXL1 is an obligate co-factor for BAP1 in H2AK119 deubiquitination.

Identifiers

PMID41756950
PMCPMC12934752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.