ArticlebioRxiv : the preprint server for biology2026
Excessive Ca
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Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
40 authors.
David R EberhardtNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-6538-8611
Emma C RekateNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0001-9415-9191
Yasmin B MasiniNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.
Hannah E DuronNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.
David MollinedoNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.
Adrian M VelardeNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0009-0001-9015-418X
Devorah StuckiDepartment of Internal Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT.
Tara PriceDepartment of Internal Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT.
Sandra H J LeeNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-8198-0367
Enrique BalderasNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0001-8780-9272
Neeraj K RaiNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-7065-7767
Ashley R BrattNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0009-0004-9114-0080
Anthony M BalynasNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0003-0741-2414
Chris J StubbenBioinformatics Shared Resource, Huntsman Cancer Institute, Salt Lake City, UT.
Ryan BiaNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-1979-7051
Sudipa MaityThermo Fisher Scientific, San Jose, CA.
Nicolas HartelThermo Fisher Scientific, San Jose, CA.
Xue YinNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.
Andrea CorbinNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0003-2626-834X
Anshu KumariDepartment of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, MD.
Dung M NguyenDepartment of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, MD.ORCID 0009-0007-6250-8271
Daisuke ShimuraNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-9954-2162
Vu D NguyenNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.
Vishaka VinodDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Kamrul H ChowdhuryDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.
Francisco VerdeguerInSphero AG, Schlieren, Switzerland.
Joel ZvickInSphero AG, Schlieren, Switzerland.
Patrice N MimcheDepartment of Dermatology, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-3761-7237
Sihem BoudinaDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.ORCID 0000-0002-4711-1109
Stavros G DrakosNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-1223-327X
Ademuyiwa S AromolaranNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-3114-2939
Sarah FranklinNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-2958-1879
Vivek GargDepartment of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0002-6940-5415
Robin M ShawNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0001-7429-6092
William L HollandDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.ORCID 0000-0001-9950-1435
Scott A SummersDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT.ORCID 0000-0002-4919-0592
Marcus G PezzolesiDepartment of Internal Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT.ORCID 0000-0002-4093-3783
Jared RutterHoward Hughes Medical Institute, Department of Biochemistry, University of Utah, Salt Lake City, UT.ORCID 0000-0002-2710-9765
Kimberley J EvasonDepartment of Pathology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0002-0471-2473
Dipayan ChaudhuriNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0003-0605-7334
Funding
Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7MCeramides as novel drivers of metabolic dysfunction and colorectal cancerU01CA272529 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Mary Christine Playdon, SCOTT A SUMMERS · 2022 to 2026
$4.7MMetabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial CardiomyopathiesR01HL141353 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2018 to 2026
$4.3MSmall molecule antagonists targeting EphB receptors for the treatment of nonalcoholic steatohepatitis (NASH)R01DK128819 · NIDDK · UNIVERSITY OF UTAH · PI MIMCHE, PATRICE · 2021 to 2025
$2.9MThe Role of Ceramides in Skeletal MuscleR01DK115824 · NIDDK · UNIVERSITY OF UTAH · PI SUMMERS, SCOTT A · 2018 to 2021
$2.6MThe Role of Ceramides in the Intestinal Stem CellR01DK131609 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI EDGAR, BRUCE ALEXANDER, SUMMERS, SCOTT A · 2021 to 2025
$2.5MRegulation of the mitochondrial calcium uniporterR01HL165797 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2022 to 2026
$2.5MThe Role of Ceramides in the Pancreatic Beta CellR01DK130296 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HOLLAND, WILLIAM L, SUMMERS, SCOTT A · 2022 to 2025
$2.2MCeramides in Diastolic Heart FailureR01HL170575 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WILLIAM L HOLLAND, SCOTT A SUMMERS · 2024 to 2026
$2.1MUnlocking Trafficking Specificity for Cx43 Gap JunctionsR01HL152691 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Robin M Shaw · 2020 to 2026
$2.0MLeukotriene B4 Regulation in HeartR01HL174450 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ademuyiwa Aromolaran · 2024 to 2026
$1.9MMechanisms of mitochondria-driven hepatocyte injuryR01DK141142 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2025 to 2026
$1.5MNCI NIH HHS U01 CA272529NHLBI NIH HHS R01 HL141353NHLBI NIH HHS R01 HL152691NHLBI NIH HHS R01 HL165797NHLBI NIH HHS R01 HL170575NHLBI NIH HHS R01 HL174450NHLBI NIH HHS R01 HL177965NIAMS NIH HHS T32 AR007592NIDDK NIH HHS R01 DK115824NIDDK NIH HHS R01 DK128819NIDDK NIH HHS R01 DK130296NIDDK NIH HHS R01 DK131609NIDDK NIH HHS R01 DK141142NIGMS NIH HHS R01 GM145806
Abstract
Metabolic-associated steatohepatitis (MASH) involves hepatocyte damage that cannot be explained solely by lipid accumulation. Here, to discover injury-specific pathways, we focused on a gene of uncertain function,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.