Evidence map›Paper›PMID 41756891›Full record

ArticlebioRxiv : the preprint server for biology2026

Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation.

Colin A Fields, James F Read, Heather Coffman, Edward P Petrow, Anthony Bosco, Deepta Bhattacharya

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Colin A FieldsDepartment of Immunobiology, University of Arizona, Tucson, AZ, 85724, USA.
James F ReadDepartment of Immunobiology, University of Arizona, Tucson, AZ, 85724, USA.
Heather CoffmanDepartment of Otolaryngology, University of Arizona, Tucson, AZ, 85724, USA.
Edward P PetrowTucson Orthopedic Institute, Tucson, AZ, 85712, USA.
Anthony BoscoDepartment of Immunobiology, University of Arizona, Tucson, AZ, 85724, USA.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona, Tucson, AZ, 85724, USA.ORCID 0000-0001-8377-7699

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4M
GLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8M
Systemic and intercellular gene networks underlying RV-induced airways diseaseR21AI176305 · NIAID · UNIVERSITY OF ARIZONA · PI BOSCO, ANTHONY · 2023 to 2024
$422k
Bill & Melinda Gates Foundation INV-007910NCI NIH HHS P30 CA023074NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI129945NIAID NIH HHS R21 AI176305
6 · The paper itself

Abstract

Upon activation, B cells undergo profound transcriptional, epigenetic, and metabolic reprogramming to form antibody secreting plasma cells bearing little resemblance to their progenitors. Here, we used single cell RNA and ATAC sequencing of primary and

Indexed as

differentiationgerminal centershuman B cellsPlasma cells

Identifiers

PMID41756891
PMCPMC12934664

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.