Evidence map›Paper›PMID 41756876›Full record

ArticlebioRxiv : the preprint server for biology2026

Loop Extrusion Accelerates Long-Range Enhancer-Promoter Searches in Living Embryos.

Pavan Choppakatla, Aleena L Patel, Tohn Borjigin, Tee Udomlumleart, Jie Hu, Thomas Gregor, Alistair N Boettiger, Michael S Levine

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pavan ChoppakatlaLewis-Sigler Institute for Integrative Genomics, Princeton University, NJ, USA.ORCID 0000-0003-0387-913X
Aleena L PatelDepartment of Developmental Biology, Stanford University, Stanford, CA, USA.
Tohn BorjiginDepartment of Chemical and Biological Engineering, Princeton University, NJ, USA.
Tee UdomlumleartDepartment of Developmental Biology, Stanford University, Stanford, CA, USA.
Jie HuLewis-Sigler Institute for Integrative Genomics, Princeton University, NJ, USA.
Thomas GregorLewis-Sigler Institute for Integrative Genomics, Princeton University, NJ, USA.ORCID 0000-0001-9460-139X
Alistair N BoettigerDepartment of Developmental Biology, Stanford University, Stanford, CA, USA.
Michael S LevineLewis-Sigler Institute for Integrative Genomics, Princeton University, NJ, USA.

Funding

Visualization of gene activity in the Drosophila embryoR35GM118147 · NIGMS · PRINCETON UNIVERSITY · PI Michael Steven Levine · 2016 to 2026
$6.7M
Live-cell multiplex super-resolution imaging of chromatin state transitionsU01DK127419 · NIDDK · STANFORD UNIVERSITY · PI BINTU, LACRAMIOARA, BOETTIGER, ALISTAIR N. · 2020 to 2024
$5.3M
NIDDK NIH HHS U01 DK127419NIGMS NIH HHS R35 GM118147
6 · The paper itself

Abstract

Long-range gene regulation underlies a variety of human developmental disorders including Cornelia de Lange syndrome

Identifiers

PMID41756876
PMCPMC12934817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.