Evidence map›Paper›PMID 41756870›Full record

ArticlebioRxiv : the preprint server for biology2026

Evidence that injury can cause

Dongkook Park, Robert M Lawrence, Tyler Jackson, Hongjie Li, Jason C Mills

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dongkook ParkDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, United States.
Robert M LawrenceDepartment of Medicine, Section of Gastroenterology & Hepatology, Baylor College of Medicine, Houston, TX, United States.ORCID 0000-0001-5269-4049
Tyler JacksonHuffington Center on Aging and Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, United States.ORCID 0000-0003-2988-4340
Hongjie LiHuffington Center on Aging and Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, United States.
Jason C MillsDepartment of Medicine, Section of Gastroenterology & Hepatology, Baylor College of Medicine, Houston, TX, United States.ORCID 0000-0002-0402-4662

Funding

REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1M
MECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4M
The Role of Inflammation in Regulating Gastric MetaplasiaR01DK134531 · NIDDK · SAINT LOUIS UNIVERSITY · PI Richard J DiPaolo · 2023 to 2026
$2.1M
NOVEL DROSOPHILA TRANSCRIPTION FACTOR ORTHOLOG OF BCL11A/BCL11B IS CRUCIAL FOR REGULATING INTESTINAL STEM CELL QUIESCENCE AND PREVENTING GUT DYSFUNCTION DURING AGINGF31DK141194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Tyler Jackson · 2025 to 2026
$100k
NIDDK NIH HHS F31 DK141194NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129NIDDK NIH HHS R01 DK134531
6 · The paper itself

Abstract

Differentiated cells can return to a progenitor-like state in response to injury via the evolutionarily conserved cellular program called paligenosis. Paligenosis proceeds by three stages: 1) autophagy/autodegradation of differentiated cell architecture, 2) metaplasia/progenitor gene induction, 3) TOR complex 1 (TORC1)-dependent cell cycle re-entry. Using multiple injury and reverse-lineage-tracing approaches in the

Indexed as

amitosiscell plasticitygastrointestinalintestinallysosomes

Identifiers

PMID41756870
PMCPMC12934638

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.