Evidence map›Paper›PMID 41756867›Full record

ArticlebioRxiv : the preprint server for biology2026

Intron Retention Controls Localization of lncRNAs

Ioannis Grammatikakis, Chosita Norkaew, You Jin Song, Amit K Behera, Erica C Pehrsson, Corrine Corrina R Hartford, Shreya Kordale, Rishabh Prasanth, Yongmei Zhao, Biraj Shrethsa and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Chosita NorkaewRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
You Jin SongDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Amit K BeheraFunctional Transcriptomics Section, RNA Biology Laboratory, NCI, NIH, Frederick, Maryland, USA.
Erica C PehrssonOMICS Technology Facility, Bioinformatics, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Corrine Corrina R HartfordRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Shreya KordaleFunctional Transcriptomics Section, RNA Biology Laboratory, NCI, NIH, Frederick, Maryland, USA.
Rishabh PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Yongmei ZhaoSequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, NCI, NIH, Frederick, Maryland, USA.
Biraj ShrethsaSequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, NCI, NIH, Frederick, Maryland, USA.
Xiao Ling LiRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ravi KumarRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ragini SinghRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Tayvia BrownmillerFunctional Genetics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Xinyu WenOMICS Technology Facility, Bioinformatics, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Natasha J CaplenFunctional Genetics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-0001-9460
Pablo Perez-PineraDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Kannanganattu V PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Thomas Gonatopoulos-PournatzisFunctional Transcriptomics Section, RNA Biology Laboratory, NCI, NIH, Frederick, Maryland, USA.ORCID 0000-0003-2669-2570
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-4299-8177

Funding

Role of long non-coding RNAs in p53 signalingZIABC011646 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAL, ASHISH · 2015 to 2025
$15.0M
Map Novel Regulatory Networks that Control Alternative SplicingZIABC012019 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONATOPOULOS-POURNATZIS, THOMAS · 2020 to 2025
$4.5M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
Characterization of nuclear-retained RNA-mediated gene regulatory mechanismsR01GM132458 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2023
$1.4M
Intramural NIH HHS ZIA BC011646Intramural NIH HHS ZIA BC012019NIBIB NIH HHS T32 EB019944NIGMS NIH HHS R01 GM132458
6 · The paper itself

Abstract

Intron retention (IR) is increasingly recognized as a feature of long noncoding RNAs (lncRNAs), yet the mechanisms that shape IR in lncRNAs and the functional consequences of this process remain largely unexplored. To investigate how IR contributes to lncRNA regulation, we performed a genome-wide screen to identify factors controlling IR in the lncRNA

Indexed as

Biological Sciencescell migrationCRISPR/Cas9intron retentionlncRNAMALAT1nuclear specklesproliferationPURPLsplicingU2AF2

Identifiers

PMID41756867
PMCPMC12934665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.