Evidence map›Paper›PMID 41756866›Full record

ArticlebioRxiv : the preprint server for biology2026

The impact of seizures on REM sleep and the cholinergic pedunculopontine nucleus in a mouse model of Dravet Syndrome.

Krystal M Santiago-Colon, Chandni Rana, Brandon Toth, Julia A Kravchenko, Joseph Barden, Isabella VanHorn, Alexandra Jack, Alexander Hollier, Rida Qureshi, Hudson Haberland and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Krystal M Santiago-ColonDepartment of Pharmacology, University of Michigan, Ann Arbor, MI USA.ORCID 0000-0003-4116-133X
Chandni RanaNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI USA.
Brandon TothNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI USA.
Julia A KravchenkoNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI USA.
Joseph BardenDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Isabella VanHornDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Alexandra JackDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Alexander HollierDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Rida QureshiDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Hudson HaberlandDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Juan DislaDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Nagham EldroubiDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Saif SiddiquiDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Sophie Erb-WatsonDepartment of Neurology, University of Michigan, Ann Arbor, MI USA.
Christian BurgessNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI USA.
Lori L IsomDepartment of Pharmacology, University of Michigan, Ann Arbor, MI USA.
Joanna MattisNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI USA.ORCID 0000-0003-0341-1270

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Neural Engineering Training Program (NETP)T32NS115724 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James D Weiland · 2021 to 2026
$1.2M
Cortico-hippocampal circuit dysfunction in an Scn1a mouse model of epilepsyK08NS121464 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MATTIS, JOANNA H · 2021 to 2025
$969k
Seizure-Induced Remodeling of Cholinergic Networks in Dravet SyndromeR01NS143722 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanna H Mattis · 2025 to 2026
$773k
Monoaminergic and limbic systems underlying narcolepsy-cataplexyF31NS132434 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brandon Anthony Toth · 2024 to 2026
$124k
The Nigrotegmental Circuit in an Scn1a+/- Mouse Model of Dravet SyndromeF31NS143195 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Chandni Rana · 2025 to 2026
$87k
NIGMS NIH HHS T32 GM140223NINDS NIH HHS F31 NS132434NINDS NIH HHS F31 NS143195NINDS NIH HHS K08 NS121464NINDS NIH HHS R01 NS143722NINDS NIH HHS T32 NS115724
6 · The paper itself

Abstract

Sleep disruption is a common and burdensome feature in epilepsy, with rapid eye movement (REM) sleep particularly affected. While sleep disturbances in epilepsy patients are multifactorial, clinical evidence suggests that recent seizures acutely impair REM sleep architecture. To investigate this relationship, we used a haploinsufficient mouse model of Dravet Syndrome, which allows experimental control of seizure timing and burden. We found that hyperthermia-induced seizures profoundly decreased subsequent sleep, specifically impairing REM entry.

Identifiers

PMID41756866
PMCPMC12934769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.