Evidence map›Paper›PMID 41756860›Full record

ArticlebioRxiv : the preprint server for biology2026

THERM-D Uncovers Distinct Neural Mechanisms Separating Morning and Evening Body Temperature Rhythms in

Tadahiro Goda, Olivia M Lopez, Richard Ramolete, Nils Reinhard, Nick Ulle, Ayumi Fukuda, Yujiro Umezaki, Kazim Rizvi, Madison G Aikawa, Roslyn Catiis and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tadahiro GodaDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Olivia M LopezDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Richard RamoleteDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Nils ReinhardNeurobiology and Genetics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Nick UlleDataLab: Data Science and Informatics, University of California Davis, One Shields Avenue, Davis CA 95616.
Ayumi FukudaGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Yujiro UmezakiDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Kazim RizviDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Madison G AikawaDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Roslyn CatiisDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Victoria Z MarquezDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Richard NgoDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Nikita RajDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Cora FisherDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Gregory T BuiDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.
Jalen LeeDataLab: Data Science and Informatics, University of California Davis, One Shields Avenue, Davis CA 95616.
Charlotte Helfrich-FörsterNeurobiology and Genetics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Taishi YoshiiGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Fumika N HamadaDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616.

Funding

Molecular and Neural Mechanisms of Temperature Preference Rhythm in DrosophilaR01GM107582 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAMADA, FUMIKA · 2013 to 2022
$3.1M
Molecular and Neural Mechanisms of Temperature Preference Rhythm in DrosophilaR35GM152154 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Fumika Hamada · 2024 to 2026
$1.3M
State-dependent modulation of taste and temperature integration in DrosophilaR34NS132843 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAMADA, FUMIKA · 2023 to 2023
$723k
Exploring the molecular mechanisms of body temperature rhythms through a Drosophila model systemR21NS112890 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GODA, TADAHIRO · 2020 to 2020
$437k
NIGMS NIH HHS R01 GM107582NIGMS NIH HHS R35 GM152154NINDS NIH HHS R21 NS112890NINDS NIH HHS R34 NS132843
6 · The paper itself

Abstract

Animal body temperature rises throughout the day and peaks in the evening, a pattern conserved across diurnal endotherms and ectotherms. However, the mechanisms driving the robust body temperature rhythms (BTR) remain largely unclear. Here, we developed a machine learning-based platform, temperature homeostasis evaluation of rhythmicity in model

Indexed as

body temperature rhythmscircadian clockCRYCRY-negative clock neuronsDrosophila melanogaster

Identifiers

PMID41756860
PMCPMC12934746

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.