Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Noah WakeDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912.ORCID 0000-0003-4119-2574
Juan AlcaldeUK Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, Basic and Clinical Neuroscience Department at Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Rd, SE5 9RT, London, United Kingdom.ORCID 0000-0002-7959-6876
Daniel JutziUK Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, Basic and Clinical Neuroscience Department at Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Rd, SE5 9RT, London, United Kingdom.ORCID 0000-0001-8381-7830
Anjali BajajDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224.ORCID 0000-0002-1008-5824
Sukhleen KourDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224.
Mayur BaraiDepartment of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 08854.ORCID 0009-0002-1022-3999
Shuo-Lin WengDepartment of Chemistry, Texas A&M University, College Station, TX, USA.ORCID 0009-0009-8082-8206
Samara CummingsDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912.ORCID 0009-0003-7605-4099
Tongyin ZhengDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912.ORCID 0000-0002-5132-6436
Eric N AndersonDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224.
Szu-Huan WangDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912.ORCID 0009-0009-8499-7066
Ryan PuterbaughDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912.ORCID 0000-0002-6412-8703
Daryl A BoscoDepartment of Neurology, UMass Chan Medical School, Worcester, MA 01605.ORCID 0000-0002-3735-3729
Benjamin S SchusterDepartment of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 08854.ORCID 0000-0002-6468-8081
Jeetain MittalDepartment of Chemistry, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-9725-6402
Udai Bhan PandeyDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224.ORCID 0000-0002-6267-0179
Marc-David RueppUK Dementia Research Institute Centre at King's College London, Institute of Psychiatry, Psychology and Neuroscience, Basic and Clinical Neuroscience Department at Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Rd, SE5 9RT, London, United Kingdom.ORCID 0000-0003-3264-9800
Nicolas L FawziDepartment of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, 02912.ORCID 0000-0001-5483-0577
Funding
Residue-by-residue details of FUS protein phase separation and aggregationR01GM147677 · NIGMS · BROWN UNIVERSITY · PI FAWZI, NICOLAS LUX · 2022 to 2025
$1.7M
Multiscale Computational Models to Investigate the Role of Phase Separation in BiologyR35GM153388 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Jeetain Mittal · 2024 to 2026
$1.3M
Interdisciplinary training in pharmacological sciencesT32GM139793 · NIGMS · BROWN UNIVERSITY · PI Diana M Horrigan, Sean Edward Lawler · 2021 to 2026
The RNA-binding protein Fused in Sarcoma (FUS) undergoes phase separation associated with RNA processing. However, the prion-like low complexity (LC) domain of FUS forms solid-like aggregates in neurodegenerative diseases. Whether the formation of β-sheet structure associated with pathology is also physiologically/functionally relevant is debated. Similarly, if mislocalization alone or concomitant aggregation is responsible for FUS gain-of-function toxicity remains to be probed. Here, we introduce β-sheet breaking proline residues into FUS LC with the goal of preventing cross-β-driven aggregation without disrupting essential functions and phase separation. β-sheet-deficient FUS variants maintain native-like global motions, disorder, and phase separation, but no longer show a liquid-to-solid transition (LST). Biochemical partitioning, cellular localization, and auto- and cross-regulatory functions of FUS all remain essentially unchanged. Conversely, FUS-induced neurodegeneration in several
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity. · full record | OpenQuestion