Evidence map›Paper›PMID 41756804›Full record

ArticleJournal of conservative dentistry and endodontics2026

Artemisinin as a novel endodontic irrigant:

Nainy Jain, Darshana Devadiga, Rahul D Rao, Manikandan Ravinanthanan, Sameep S Shetty, Astrid Ana Gomes

Abstract read
In one paragraph

Article in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nainy JainDepartment of Conservative Dentistry and Endodontics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, India.
Darshana DevadigaDepartment of Conservative Dentistry and Endodontics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, India.
Rahul D RaoDepartment of Conservative Dentistry and Endodontics, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Navi Mumbai, Maharashtra, India.
Manikandan RavinanthananFaculty of Dentistry, Restorative Dental Sciences, Al Baha University, Saudi Arabia.
Sameep S ShettyDepartment of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Astrid Ana GomesDepartment of Conservative Dentistry and Endodontics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Artemisinin is a sesquiterpene lactone extracted from Aims: To evaluate the Subjects and Methods: The antimicrobial activity was determined using the ditch plate method and the antioxidant capacity was evaluated using the total antioxidant assay with optical density measured at 695 nm, while FTIR spectroscopy analysis revealed the functional groups present in artemisinin extract. Results: Artemisinin exhibited significant inhibitory activity, against both the test microrganisms. The antioxidant analysis revealed a concentration-dependent increase in activity, with the highest effect at 10 mg/mL (2.08 mm/L). FTIR spectra showed multiple absorption bands corresponding to hydroxyl, phenolic, and aliphatic groups, indicating complex molecular characteristics. Conclusions: Artemisinin demonstrates dual antimicrobial and antioxidant properties, suggesting its potential as a safer, biologically compatible endodontic irrigant. To validate the

Indexed as

AntioxidantsartemisininCandida albicansEnterococcus faecalisroot canal irrigants

Identifiers

PMID41756804
PMCPMC12935430

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.