ReviewChemical & biomedical imaging2026
Seeing the Unseen: Super-Resolution Microscopy in Protein Aggregation Research.
Review in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Imaging from Macro to Nanoscale: Multimodal Advances in Chemical and Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- 3D Expansion-PALM (PhotoActivated Localization Microscopy) Dissects Protein-Protein Interactions Down to the Molecular Scale in Bacteria.Microorganisms · 2026Article
- Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics.Advanced drug delivery reviews · 2026Review
- Protein aggregation as a bistable switch in bacterial cell fate: from adaptive dormancy to cytotoxic death.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Super-resolution microscopy surpasses the diffraction limit and enables the visualization of biomolecular structures with unprecedented detail. These techniques have been widely used in many scientific areas, including cell biology, genomics, microbiology, and material science. In the field of protein aggregation, a process intimately linked to numerous neurodegenerative diseases, the high spatial resolution of super-resolution microscopy enables the direct observation of the fine structure of different species, ranging from small oligomers to mature aggregates, providing insights into molecular aggregation mechanisms and the pathology of neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's disease. In this review, we outline the principles of three major super-resolution microscopy techniques, including stimulated emission depletion (STED), structured illumination microscopy (SIM), and single-molecule localization microscopy (SMLM), and compare their respective strengths and limitations in studying protein aggregation. We then highlight the recent applications of these techniques in studying protein aggregation, with a focus on aggregate morphology, dynamic formation processes, and interactions with cellular components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.