ArticleInternational journal of particle therapy2026
Comparing Organs at Risk Sparing Between Intensity-Modulated Radiotherapy and Pencil-Beam Scanning Plans Based on Disease Location for Hodgkin and Non-Hodgkin Lymphoma.
Article in International journal of particle therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Radiotherapy (RT) is often used as a combined modality therapy for patients with Hodgkin (HL) and aggressive Non-Hodgkin Lymphoma (aNHL). RT options include photon intensity-modulated radiotherapy (IMRT) or proton therapy (PT). As PT is a limited and costly resource, it is important to identify cases in which PT may best benefit in order to offer providers and patients the best possible information for decision-making. Accordingly, the purpose of this study was to assess the difference in OAR sparing between photon IMRT and pencil-beam scanning (PBS) based on disease location using the Ann Arbor (AA) staging system. Materials and Methods: A cohort was established including all patients with HL or aNHL ( Results: PBS reduced the mean heart dose with the largest AS (6.4 Gy) for patients with UML mediastinal involvement. Greatest AS and RS for lung V20 was seen for patients with bilateral axillary involvement (20.9% AS, 53.5% RS), and for mean breast dose greatest sparing was seen for those with bilateral hilar disease (5.1 Gy AS, 58.6% RS). Conclusion: The use of PBS resulted in a substantial decrease in the mean dose to OARs, the magnitude of which depended on the location in which disease was present. This work advances that the anatomic location of involvement is an important influence on the relative benefit of PT.
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