Evidence map›Paper›PMID 41756729›Full record

ArticleiScience2026

Progesterone-driven stabilization of hybrid E/M states in amniotic epithelial cells enhances regeneration and immune modulatory capacities.

Angelo Canciello, Alberto Maria Crovace, Verdiana Di Giulio, Giuseppe Prencipe, Mohammad El Khatib, Valentina Russo, Marta Guadalupi, Annunziata Mauro, Antonio Crovace, Oriana Di Giacinto and 4 more

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Angelo CancielloDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Alberto Maria CrovaceDepartment of Veterinary Medicine, University of Sassari, Sassari 07100, Italy.
Verdiana Di GiulioDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Giuseppe PrencipeDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Mohammad El KhatibDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Valentina RussoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Marta GuadalupiDepartment of Precision and Regenerative Medicine and Jonic Area (DiMePre-J) University of Bari-Aldo Moro, Bari 70121, Italy.
Annunziata MauroDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Antonio CrovaceDepartment of Emergency and Organ Transplantation, University of Bari "Aldo Moro", Bari 70124, Italy.
Oriana Di GiacintoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Maura TurrianiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.
Laura PierdomenicoDepartment of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology (CAST), G. D'Annunzio University Chieti-Pescara, Chieti 66100, Italy.
Marco MarchisioDepartment of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology (CAST), G. D'Annunzio University Chieti-Pescara, Chieti 66100, Italy.
Barbara BarboniDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo 64100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-mesenchymal plasticity (EMP) plays a pivotal role in development, regeneration, and disease progression. In this study, we demonstrate that progesterone (P4) delays EMP in amniotic epithelial cells (AECs), promoting the emergence of hybrid epithelial/mesenchymal (E/M) phenotypes. These hybrid cells co-express E and M traits and exhibit distinct surface markers. Compared to fully M, hybrid AECs display enhanced collective migration, upregulation of stemness transcription factors, and enhanced immunomodulatory properties

Indexed as

Developmental biologyImmunologyMolecular biology

Identifiers

PMID41756729
PMCPMC12933622

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.