Evidence map›Paper›PMID 41756712›Full record

ArticleRSC chemical biology2026

Discovery of natural products that modulate signaling in patient-derived cells.

Joseph A Balsamo, Hannah L Thirman, Kathryn E Penton, Jordan T Froese, Benjamin J Reisman, Sierra M Lima, Madeline J Grider-Hayes, Chad R Potts, Jonathan M Irish, P Brent Ferrell and 1 more

Abstract read
In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph A BalsamoDepartment of Pharmacology, Vanderbilt University, Vanderbilt University School of Medicine Nashville Tennessee USA brian.bachmann@vanderbilt.edu.ORCID https://orcid.org/0000-0003-3646-9364
Hannah L ThirmanProgram in Chemical & Physical Biology, Vanderbilt University School of Medicine Nashville Tennessee USA.ORCID https://orcid.org/0000-0002-3735-9995
Kathryn E PentonDepartment of Chemistry, Vanderbilt University Nashville Tennessee USA.ORCID https://orcid.org/0000-0001-8417-4849
Jordan T FroeseDepartment of Chemistry, Ball State University 2000 W. University Ave Muncie USA.ORCID https://orcid.org/0000-0001-6612-4127
Benjamin J ReismanProgram in Chemical & Physical Biology, Vanderbilt University School of Medicine Nashville Tennessee USA.ORCID https://orcid.org/0000-0001-7847-2612
Sierra M LimaDepartment of Cell & Developmental Biology, Vanderbilt University Nashville Tennessee USA.ORCID https://orcid.org/0000-0001-5944-750X
Madeline J Grider-HayesDepartment of Cell & Developmental Biology, Vanderbilt University Nashville Tennessee USA.ORCID https://orcid.org/0000-0003-3684-9885
Chad R PottsVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA.ORCID https://orcid.org/0000-0003-2319-2474
Jonathan M IrishDepartment of Cell & Developmental Biology, Vanderbilt University Nashville Tennessee USA.ORCID https://orcid.org/0000-0001-9428-8866
P Brent FerrellVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center Nashville Tennessee USA.ORCID https://orcid.org/0000-0003-1140-9154
Brian O BachmannDepartment of Pharmacology, Vanderbilt University, Vanderbilt University School of Medicine Nashville Tennessee USA brian.bachmann@vanderbilt.edu.ORCID https://orcid.org/0000-0001-5815-1176

Funding

ONCOLOGY: CHEMOTHERAPY, IMMUNOLOGY, BIOLOGYT32CA009071 · NCI · JOHNS HOPKINS UNIVERSITY · PI Mary Y Armanios, Nilofer S. Azad · 1985 to 2026
$12.8M
Single Cell Methods for Bioeffector Discovery and AnalysisR01CA226833 · NCI · VANDERBILT UNIVERSITY · PI BRIAN O BACHMANN, Jonathan Michael Irish · 2019 to 2026
$6.1M
NCI NIH HHS R01 CA226833NCI NIH HHS T32 CA009071
6 · The paper itself

Abstract

Natural products derived from biosynthetically apt microorganisms represent an important source for chemotherapeutic agents founded first

Identifiers

PMID41756712
PMCPMC12933418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.