Evidence map›Paper›PMID 41756684›Full record

ArticleACS sustainable chemistry & engineering2026

Stable and Water-Tolerant Deep Eutectic Solvent from Biomass-Derived 5‑Hydroxymethylfurfural (HMF) and Levulinic Acid.

Grazia Isa C Righetti, Sara Rozas, Maria Enrica Di Pietro, Sara Santamaría, Sahar Nasrallah, Mirjana Minceva, Francesco Briatico Vangosa, Santiago Aparicio, Andrea Mele

Abstract read
In one paragraph

Article in ACS sustainable chemistry & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grazia Isa C RighettiDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 20133 Milano, Italy.ORCID https://orcid.org/0000-0002-7539-6885
Sara RozasDepartment of Chemistry, University of Burgos, 09001 Burgos, Spain.ORCID https://orcid.org/0000-0003-2571-2971
Maria Enrica Di PietroDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 20133 Milano, Italy.ORCID https://orcid.org/0000-0002-2370-1948
Sara SantamaríaDepartment of Chemistry, University of Burgos, 09001 Burgos, Spain.
Sahar NasrallahBiothermodynamics, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.ORCID https://orcid.org/0009-0008-5076-7089
Mirjana MincevaBiothermodynamics, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.ORCID https://orcid.org/0000-0001-9820-7410
Francesco Briatico VangosaDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 20133 Milano, Italy.ORCID https://orcid.org/0000-0002-7088-1064
Santiago AparicioDepartment of Chemistry, University of Burgos, 09001 Burgos, Spain.ORCID https://orcid.org/0000-0001-9996-2426
Andrea MeleDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 20133 Milano, Italy.ORCID https://orcid.org/0000-0002-0351-0538

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of greener extraction systems is essential to improving the sustainability of biomass valorization processes. Here we report that 5-hydroxymethylfurfural (HMF) and levulinic acid (LEV)two bioderived platform molecules often coproduced in biomass processingspontaneously form a stable liquid phase over a broad compositional range. Differential scanning calorimetry (DSC) and thermodynamic modeling reveal a eutectic composition near

Indexed as

DESHMFHydroxymethylfurfurallevulinic acidmolecular dynamicsNMR spectroscopyphase-diagramsolid−liquid equilibriumsustainable chemistry

Identifiers

PMID41756684
PMCPMC12934199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.