Evidence map›Paper›PMID 41756678›Full record

ArticleHuman mutation2026

P4HA2 Participates in Pathogenesis of Refractive Error by Regulating Collagen Posttranslational Modification and Extracellular Matrix Balance.

Yanling Liu, Shanshan Dong, Furong Huang, Ruotong Li, Xi He, Yizheng Jiang, Qi Tian, Haofeng Xiong, Liangyun Jin, Qiongsi Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yanling LiuCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-1799-8044
Shanshan DongGMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.ORCID https://orcid.org/0000-0002-1605-7066
Furong HuangSchool of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Ruotong LiCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Xi HeDepartment of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou, China, zju.edu.cn.
Yizheng JiangCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Qi TianCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Haofeng XiongCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Liangyun JinElectron Microscope Room of Central Laboratory, Capital Medical University, Beijing, China, ccmu.edu.cn.
Qiongsi WangSchool of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Lu XiaCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Jingjing ChenCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Huidan WuCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Hui GuoCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.
Xiangtian ZhouSchool of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Kun XiaCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0001-8090-6002
Zhengmao HuCenter for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-3921-8205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myopia represents a refractive anomaly characterized by impaired vision resulting from a misfocused image in front of the fovea. Although numerous genes linked to high myopia (HM) have been identified, the exact etiology and pathogenesis mechanisms of HM remain predominantly obscure. In a prior investigation, a mutation in the

Indexed as

CollagenExtracellular MatrixMyopiaProcollagen-Proline DioxygenaseProtein Processing, Post-TranslationalRefractive ErrorsAnimalsCorneaDisease Models, AnimalHEK293 CellsHumansMiceMice, KnockoutScleraCollagenProcollagen-Proline Dioxygenasecollagen hydroxylationcollagen thermal stabilityextracellular matrix (ECM)high myopia (HM)prolyl 4-hydroxylase ii (P4HA2)refractive error

Identifiers

PMID41756678
PMCPMC12933143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.