ArticleFrontiers in cell and developmental biology2026
Cumulative burden of maternal vascular malperfusion and its association with early cerebral oxygenation in neonates.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Maternal vascular malperfusion (MVM) represents a major cause of chronic fetal hypoxia and is associated with adverse neonatal outcomes. However, whether the cumulative burden of MVM lesions influences early cerebral oxygenation in neonates remains unclear. This study aimed to evaluate the association between the number of placental MVM lesion types and neonatal cerebral regional oxygen saturation (crSO Methods: In this retrospective observational study, 508 neonates admitted between January 2021 and March 2024 were included. Based on placental histopathology, infants were categorized into three groups according to the number of MVM lesion types: no MVM, 1-2 MVM types, and 3-5 MVM types. Cerebral oxygenation was monitored weekly from birth to postnatal day 28 using near-infrared spectroscopy. Multivariable linear regression models were used to assess associations between MVM burden and crSO Results: Compared with neonates without MVM, those with placental findings of 3-5 types of MVM had significantly higher crSO Conclusion: A cumulative burden of 3-5 MVM types is independently associated with altered cerebral oxygenation patterns in the early neonatal period, characterized by higher crSO
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