Evidence map›Paper›PMID 41756667›Full record

ArticleFrontiers in plant science2026

A time-resolved metabolomics study of potato cultivar responses to

Lindiwe Mahlangu, Khayalethu Ntushelo, Ntakadzeni Edwin Madala, Phumzile Sibisi

Abstract read
In one paragraph

Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lindiwe MahlanguDepartment of Agriculture and Animal Health, University of South Africa, Johannesburg, South Africa.
Khayalethu NtusheloDepartment of Agriculture and Animal Health, University of South Africa, Johannesburg, South Africa.
Ntakadzeni Edwin MadalaDepartment of Biochemistry and Microbiology, University of Venda, Thohoyandou, South Africa.
Phumzile SibisiDepartment of Agriculture and Animal Health, University of South Africa, Johannesburg, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The bacterial plant pathogen Methods: This study employed an untargeted LC-MS metabolomics to investigate dynamic metabolic reprogramming in contrasting potato cultivars, Sifra and Valor, following inoculation with Results: Our results revealed distinct, genotype-specific response kinetics. Neither cultivar exhibited significant pathogen-responsive metabolomic reprogramming at 24 hours post-inoculation. At 48 hours post-inoculation, levels of 14 metabolites were elevated in the inoculated Valor samples, while Sifra showed minimal reprogramming. The Valor responses were not sustained and had subsided at the 72 hour time point. Meanwhile, by 72 hours, a spike in 11 metabolites was observed in the inoculated Sifra, with almost no upregulation of these in Valor. Among the spiked metabolites in Valor and Sifra were metabolites with a proven role in pathogen response. In total, there were 5 overlapping heightened metabolites between Valor and Sifra. Discussion: While cultivars are expected to differ in their response to pathogen inoculation, resistance mechanisms and timing of response remain obscure and the present study uncovered varied time-dependent pathogen-induced metabolomic shifts of the two cultivars. This study added the much-needed knowledge of resistance responses with a new suite of response metabolites.

Indexed as

flavonoidsglycoalkaloidslipid signallingmetabolomicsphenylpropanoid pathwaypotato cultivarsPseudomonas syringaeresistance biomarkers

Identifiers

PMID41756667
PMCPMC12934511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.