ArticleFrontiers in veterinary science2026
Validation of +tiDx: a point-of-care diagnostic system for Gram-positive bovine mastitis.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Rapid and accurate detection and identification of bovine mastitis-causing pathogens are crucial for treatment decisions and dairy farm management. In this work, we developed and validated a diagnostic system for point-of-care applications that may properly detect and identify Methodology: A total of 520 milk samples from cows with somatic cell count (SCC) < 200,000 cells/ml, or < 100,000 cells/ml for primiparous cows, which were deemed free of intramammary infection, and subclinical mastitis cows (>200,000 cells/ml, or >100,000 cells/ml for primiparous cows) were analyzed using the +tiDx system and a composite reference standard (CRS), which included standard microbiological culture (SMC) and SCC as testing conditions, to assess diagnostic performance for detection and identification of Gram-positive pathogens. We evaluated our diagnostic system by REASSURED criteria against the SMC. Results: The +tiDx diagnostic system demonstrated adequate overall performance relative to CRS for the detection of mastitis caused by Gram-positive bacteria, achieving a sensitivity of 0.98 and a specificity of 0.94 relative to CRS. Regarding its performance relative to CRS against specific pathogens, the system yielded varied yet noteworthy results depending on the evaluated species: a sensitivity of 0.65 and specificity of 0.94 for Conclusion: +tiDx is a practical and reliable on-farm diagnostic tool for Gram-positive intramammary infections, combining timeliness and ease of use with appropriate user training to ensure accurate result interpretation and support effective mastitis control.
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