Evidence map›Paper›PMID 41756572›Full record

ArticleFrontiers in psychiatry2026

Alterations in subgenual anterior cingulate cortex functional connectivity underlie depressive symptoms in chronic insomnia disorder.

Yuan He, Shaoxiang Zhong, Duan Liu, Haoyu Li, Junyao Wang, Yanling Chen, Ronghua Xu, Chunhua Xi, Liang Gong

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Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuan He *North Sichuan Medical College, Department of Neurology, West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Nanchong, Sichuan, China.
Shaoxiang Zhong *Department of Neurology, The affiliated Hospital of Southwest Medical University, Chengdu Second People's Hospital, Luzhou, Sichuan, China.
Duan Liu *Department of Neurology,West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Sichuan Provincial Engineering Research Center of Brain-macine Interactive Neurodulation, Chengdu, Sichuan, China.
Haoyu LiChengdu Medical College, Department of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Junyao WangChengdu Medical College, Department of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Yanling ChenNorth Sichuan Medical College, Department of Neurology, West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Nanchong, Sichuan, China.
Ronghua XuDepartment of Neurology,West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Sichuan Provincial Engineering Research Center of Brain-macine Interactive Neurodulation, Chengdu, Sichuan, China.
Chunhua XiDepartment of Neurology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Liang GongDepartment of Neurology,West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Sichuan Provincial Engineering Research Center of Brain-macine Interactive Neurodulation, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic insomnia disorder (CID) and depression exhibit high comorbidity, yet the underlying neurobiological mechanisms remain poorly understood. Neuroimaging meta-analyses suggest the subgenual anterior cingulate cortex (sgACC) is a key node, but the characteristics of its network connectivity in CID patients with depressive symptoms (CID-D) are unclear. Methods: This study enrolled 197 participants: 66 CID patients without depression (CID-nD), 67 CID-D patients, and 64 good sleep controls (GSC). Using resting-state functional magnetic resonance imaging (fMRI), we compared sgACC-based functional connectivity (FC) across groups. We also examined correlations between altered FC and clinical symptoms, and investigated whether altered sgACC FC mediated the relationship between insomnia severity and depressive symptoms. Results: Significant group differences in sgACC FC were found in the left inferior temporal gyrus (ITG), inferior frontal gyrus (IFGtri), right supplementary motor area (SMA), postcentral gyrus (POCG), and medial superior frontal gyrus (SFGmed). Specifically, compared to CID-nD, CID-D patients showed increased FC with ITG.L and IFGtri.L, and decreased FC with SMA.R and POCG.R. FC between sgACC and ITG.L or IFGtri.L was positively correlated with depressive symptoms, while sgACC-POCG.R FC was negatively correlated. Mediation analysis revealed that sgACC-ITG.L FC partially mediated the link between insomnia and depressive symptoms. Conclusion: Our findings identify specific alterations in sgACC functional network in CID patients with comorbid depression. The mediating role of sgACC-ITG.L connectivity highlights a potential neural pathway through which insomnia contributes to depressive symptoms, identifying a putative target for neuromodulation therapies.

Indexed as

depressionfunctional connectivityinsomniaresting-state functional magnetic resonance imagingsubgenual anterior cingulate cortex

Identifiers

PMID41756572
PMCPMC12932571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.