ArticleRadiology case reports2026
An unusual case of IgG4-related disease presenting as lower limb fasciitis.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect nearly any organ. We report an unusual case of IgG4-RD presenting as gradually progressing bilateral lower limb fasciitis in a 29-year-old male patient. He was initially diagnosed with lower limb cellulitis; however, the symptoms did not improve with long courses of intravenous antibiotics. Autoimmune screen was negative and there were no features to suggest an underlying atypical infection. Subsequent cross-sectional imaging demonstrated deep fasciitis in both lower legs and a deep incision biopsy showed characteristic storiform IgG4 plasma cell tissue infiltration. The patient had an excellent clinical response to steroid and immunosuppressant therapy. IgG4-RD should be considered as a differential diagnosis in a patient presenting with prolonged, unexplained soft tissue swelling, even if there are no other sites of involvement.
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