Harnessing NIR-II-responsive Rh single-atom nanozymes for photothermal-catalytic immunomodulation and eradication of drug-resistant biofilms in deep tissues.

Bangxun Mao, Binge Huang, Mengru Li, Wentao Zhang, Qian Chang, Xiaojun He, Shihao Xu

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Bangxun MaoDepartment of Ophthalmology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.

Binge HuangSchool of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Mengru LiDepartment of Ultrasound Medicine, National Key Clinical Specialty (Wound Healing), Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical Translation, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Wentao ZhangDepartment of Ultrasound Medicine, National Key Clinical Specialty (Wound Healing), Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical Translation, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Qian ChangDepartment of Ultrasound Medicine, National Key Clinical Specialty (Wound Healing), Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical Translation, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Xiaojun HeDepartment of Ophthalmology, Peking University First Hospital, Beijing, 100034, China.

Shihao XuDepartment of Ultrasound Medicine, National Key Clinical Specialty (Wound Healing), Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical Translation, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising incidence of multidrug-resistant (MDR) bacterial infections in deep tissues, such as subcutaneous abscesses and bacterial pneumonia, has become an urgent public health concern. Both conventional antibiotic treatments and nanomaterial-based therapies are inadequate due to their limited catalytic efficiency, poor tissue penetration, and the enhanced resistance they provoke. We report the rational design and synthesis of nitrogen-doped rhodium single-atom catalysts (Rh SACs) that integrate second near-infrared (NIR-II) photothermal conversion with multienzyme mimetic activities. This nanozyme platform employs a synergistic 'photothermal-catalytic' therapy to effectively eliminate MDR pathogens and disrupt biofilms. Density functional theory (DFT) calculations indicate that atomically dispersed Rh sites lower the reaction barrier and optimize the adsorption of intermediates. The presence of rhodium enhances peroxidase and oxidase-mimetic activities under NIR-II irradiation. Transcriptional analysis reveals that Rh SACs modulate inflammation signaling and the immune microenvironment at the molecular level. In mice with methicillin-resistant

Indexed as

Antibacterial and antibiofilmBacterial pneumoniaNanozymeRhodium single-atom catalystWound healing

Identifiers

PMID41756525

DOI10.1016/j.mtbio.2026.102910

PMCPMC12933783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.