Evidence map›Paper›PMID 41756511›Full record

ReviewFrontiers in cardiovascular medicine2026

Direct oral anticoagulants are effective in preventing but not resolving radial artery occlusion: a systematic review and meta-analysis of randomized controlled trials.

Amal A Alsubaiei, Abdullatif A Alfehaid, Mooza M Alzayed, Ali Saad Artam, Osama T Almutairi, Mohammed S A Alajmi, Yaqeen H Alaraibi, Abdullah A Alibrahim, Omar F Alawadhi, Abdullah M Alharran

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amal A AlsubaieiKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Abdullatif A AlfehaidRoyal College of Surgeons in Ireland, Busaiteen, Bahrain.
Mooza M AlzayedCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
Ali Saad ArtamKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Osama T AlmutairiRoyal College of Surgeons in Ireland, Busaiteen, Bahrain.
Mohammed S A AlajmiCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
Yaqeen H AlaraibiRoyal College of Surgeons in Ireland, Busaiteen, Bahrain.
Abdullah A AlibrahimRoyal College of Surgeons in Ireland, Busaiteen, Bahrain.
Omar F AlawadhiRoyal College of Surgeons in Ireland, Busaiteen, Bahrain.
Abdullah M AlharranCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This systematic review, including a meta-analysis, aimed to investigate the efficacy and safety of direct oral anticoagulants (DOACs) in preventing and resolving radial artery occlusion (RAO) following transradial artery access. Methods: We synthesized evidence from randomized controlled trials (RCTs) identified in PubMed, CENTRAL, Scopus, and Web of Science up to May 2025. Using Stata MP v. 17, we employed a fixed-effects model to report dichotomous outcomes, presenting relative risk ratio (RR) with a 95% confidence interval (CI). Trial sequential analysis (TSA) was conducted to investigate the robustness and reliability of the cumulative evidence. Results: Four RCTs with 970 participants were included. DOACs significantly decreased the incidence of RAO [RR: 0.49, 95% (0.31, 0.79), Conclusion: DOACs significantly prevented the incidence of RAO, although TSA indicates that this finding is not yet conclusive. No significant differences were found between groups regarding RAO resolution or the incidence of hematoma, minor bleeding, or major bleeding. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251063999.

Indexed as

angiographyapixabanedoxabanpercutaneous coronary intervention (PCI)rivaroxabantransradial

Identifiers

PMID41756511
PMCPMC12932602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.