ArticleResearch square2026
Targeted regeneration of post-radiation epithelium without promoting cancer recurrence.
Qiwen Gan, Ya-Wen Chen, Eric Genden, Michael Berger, Zhuhao Wu, Alison May, Zhe Ying
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Qiwen GanDepartment of Stem Cell Biology and Regenerative Medicine, Institute of Regenerative Medicine, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.ORCID https://orcid.org/0000-0001-8945-5930 Ya-Wen ChenDepartment of Stem Cell Biology and Regenerative Medicine, Institute of Regenerative Medicine, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.ORCID https://orcid.org/0000-0003-2382-8444 Eric GendenDepartment of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Michael BergerDepartment of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Zhuhao WuHelen and Robert Appel Institute for Alzheimer's Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, 413 E 69th St, New York, NY 10021, USA.ORCID https://orcid.org/0000-0002-2471-0555 Alison MayDepartment of Stem Cell Biology and Regenerative Medicine, Institute of Regenerative Medicine, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Zhe YingDepartment of Stem Cell Biology and Regenerative Medicine, Institute of Regenerative Medicine, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Funding
Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2MMechanisms of salivary epithelium-specific expansion post-irradiationR01DE034100 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZHE YING · 2025 to 2026
$1.4MFunctional exploration of progenitor renewal and differentiation in oral epithelial homeostasis and cancerR00DE029229 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YING, ZHE · 2021 to 2023
$744kNIAMS NIH HHS P30 AR079200NIDCR NIH HHS R00 DE029229NIDCR NIH HHS R01 DE034100
6 · The paper itselfAbstract
Cancer radiotherapy inevitably damages normal tissues, yet therapeutic activation of pro-survival or regenerative pathways frequently increases the risk of cancer recurrence. Strategies that selectively restore normal tissue without fueling malignant regrowth remain largely undefined. Using the slow dividing yet radio-responsive salivary gland and adjacent oral squamous cell carcinoma (OSCC) as paired
Identifiers
PMID41756468
PMCPMC12934974
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