Evidence map›Paper›PMID 41756467›Full record

ArticleResearch square2026

Recognition of Non-standard Base Pairs by Triplex-Forming Oligonucleotides Containing an Expanded Genetic Alphabet.

Michael Brazzill, Ruolin Ma, Kieron Munn, Léna Prestifilippo, Andrew R Pickford, Hyo-Joong Kim, Cen Chen, Shuichi Hoshika, Steven A Benner, David A Rusling

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Michael BrazzillSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
Ruolin MaSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
Kieron MunnSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
Léna PrestifilippoSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
Andrew R PickfordCentre for Enzyme Innovation, School of the Environment and Life Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.ORCID 0000-0002-7237-0030
Hyo-Joong KimFoundation for Applied Molecular Evolution, Alachua, FL 32615, USA.
Cen ChenFoundation for Applied Molecular Evolution, Alachua, FL 32615, USA.ORCID 0000-0002-6883-9369
Shuichi HoshikaFoundation for Applied Molecular Evolution, Alachua, FL 32615, USA.ORCID 0000-0001-9128-1183
Steven A BennerFoundation for Applied Molecular Evolution, Alachua, FL 32615, USA.
David A RuslingSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.

Funding

Basic Research for Diagnostics and Surveillance in Lower Resource EnvironmentsR01AI135146 · NIAID · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · PI BENNER, STEVEN A · 2021 to 2024
$2.8M
NIAID NIH HHS R01 AI135146
6 · The paper itself

Abstract

The sequence-specific recognition of double-stranded DNA by biocompatible molecules is fundamental to molecular medicine and synthetic biology. Triplex-forming oligonucleotides (TFOs) enable programmable major-groove recognition

Identifiers

PMID41756467
PMCPMC12934894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.