Evidence map›Paper›PMID 41756457›Full record

ArticleResearch square2026

Gut Microbiota Mediate the Metabolism of Colonic Prostaglandins.

Nan Jing, Guodong Cao, Han Qiao, Matthew L Edin, Katherine Z Sanidad, Yige Wang, Eleanor Zhu, Jianzhong Ge, Jun Yang, Fred B Lih and 22 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Nan JingDepartment of Nutrition, University of California, Davis, CA, USA.
Guodong CaoState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
Han QiaoState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
Matthew L EdinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.
Katherine Z SanidadGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Yige WangDepartment of Nutrition, University of California, Davis, CA, USA.
Eleanor ZhuGenome Center, University of California, Davis, CA, USA.
Jianzhong GeBiological and Agricultural Engineering, University of California, Davis, CA, USA.
Jun YangDepartment of Entomology and Nematology, University of California, Davis, CA, USA.ORCID 0000-0001-8126-1728
Fred B LihDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.ORCID 0000-0002-2260-816X
Emma LuuGenome Center, University of California, Davis, CA, USA.
Augustine ArredondoGenome Center, University of California, Davis, CA, USA.
Lauren E HutchinsonDepartments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0009-0008-1712-7186
Quancai SunDepartment of Food Science and Technology, National University of Singapore, Singapore.
Jianan ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Vladimir YeliseyevMassachusetts Host-Microbiota Center, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Jonathan C P SteeleHypha Discovery Limited, Abingdon, United Kingdom.
Richard K PhippsHypha Discovery Limited, Abingdon, United Kingdom.
Stephen K WrigleyHypha Discovery Limited, Abingdon, United Kingdom.
Tetsuo KokubunHypha Discovery Limited, Abingdon, United Kingdom.
Ravi N ManoharHypha Discovery Limited, Abingdon, United Kingdom.
Emily HopkinsHypha Discovery Limited, Abingdon, United Kingdom.ORCID 0009-0004-7639-5843
Yi WangBiological and Agricultural Engineering, University of California, Davis, CA, USA.
Ginger L MilneDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sunny Hei WongLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-3354-9310
Andreas J BäumlerDepartment of Medical Microbiology and Immunology, University of California, Davis, CA, USA.ORCID 0000-0001-9152-7809
Justin B SiegelGenome Center, University of California, Davis, CA, USA.
Matthew R RedinboDepartments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0814-5346
Melody Y ZengGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-0031-4267
Darryl C ZeldinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.
Zongwei CaiState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
Guodong ZhangDepartment of Nutrition, University of California, Davis, CA, USA.ORCID 0000-0001-7780-5470

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
TO AWARD THE BASE PERIOD FOR NIMH PSYCHOACTIVE DRUG SCREENING PROGRAM (PDSP). BASE POP: 08/30/2023-08/29/2024.75N95023C00021 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN · 2023 to 2025
$9.0M
Megakaryocyte regulation by the gut microbiomeR01HL169989 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Melody Y Zeng · 2023 to 2026
$2.6M
P450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2M
Gut Microbial Enzymes and Human DiseaseR35GM152079 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Matthew R Redinbo · 2024 to 2026
$1.6M
Immune regulation by the gut microbiome at the maternal-fetal interfaceR01HD110118 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZENG, MELODY Y · 2022 to 2024
$1.3M
Intramural NIH HHS Z01 ES025034NHLBI NIH HHS R01 HL169989NICHD NIH HHS R01 HD110118NIDDK NIH HHS P30 DK034854NIGMS NIH HHS R35 GM152079NIH HHS 75N95023C00021
6 · The paper itself

Abstract

Prostaglandins (PGs) are endogenous lipid signaling molecules that regulate diverse physiological and pathological processes, and their biosynthetic pathways are targets of widely used drugs such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)

Identifiers

PMID41756457
PMCPMC12934979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.