Evidence map›Paper›PMID 41756449›Full record

ArticleResearch square2026

BRD1 haploinsufficiency alters early neuronal programming and disrupts maturation in human induced glutamatergic neurons.

Per Qvist, Julie Donskov, P J Deans, Dimitrios Pediotidis-Maniatis, Jacob Høgfeldt, Anders Borglum, Mark Denham, Kristen Brennand

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Per QvistAarhus University.ORCID 0000-0002-0750-0089
Julie Donskov
P J Deans
Dimitrios Pediotidis-Maniatis
Jacob Høgfeldt
Anders BorglumAarhus University.ORCID 0000-0001-8627-7219
Mark DenhamDepartment of Biomedicine, Aarhus University.ORCID 0000-0001-5279-5915
Kristen BrennandYale University.ORCID 0000-0003-0993-5956

Funding

High-throughput in vivo and in vitro functional and multi-omics screens of neuropsychiatric and neurodevelopmental disorder risk genesRM1MH132648 · NIMH · YALE UNIVERSITY · PI Kristen Jennifer Brennand, Rong Fan · 2023 to 2026
$5.6M
Functional convergence following disruption of diverse genes associated with neurodevelopmental disordersR01MH123155 · NIMH · YALE UNIVERSITY · PI BRENNAND, KRISTEN JENNIFER, RUDERFER, DOUGLAS · 2021 to 2025
$4.1M
NIMH NIH HHS R01 MH123155NIMH NIH HHS RM1 MH132648
6 · The paper itself

Abstract

BRD1 is an epigenetic regulator implicated in neurodevelopmental and psychiatric disorders, yet its role in human neuronal differentiation, maturation, and function remains poorly understood. Here we show that

Identifiers

PMID41756449
PMCPMC12934982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.