Evidence map›Paper›PMID 41756441›Full record

ArticleResearch square2026

György Haskó, Luyu Liu, Zoltán H Németh, Gebhard Wagener, Ugur Akcan, Muhammed Arif, Pál Pacher, Taha Kelestemur

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

György HaskóDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Luyu LiuPurine Pharmaceuticals, Inc., East Hanover, NJ.
Zoltán H NémethDepartment of Surgery, Morristown Medical Center, Morristown, NJ, USA.
Gebhard WagenerDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Ugur AkcanDepartment of Neurology, Columbia University, New York, NY, USA.
Muhammed ArifLaboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Pál PacherLaboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Taha KelestemurDepartment of Anesthesiology, Columbia University, New York, NY, USA.

Funding

Purinergic signaling in trauma and sepsisR01GM066189 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI HASKO, GEORGE · 2002 to 2020
$4.7M
Neutrophil A2A receptors in sepsisR01HL158519 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HASKO, GEORGE · 2021 to 2024
$2.1M
CD73 for sepsisR41AI149789 · NIAID · PURINE PHARMACEUTICALS, INC. · PI HASKO, GEORGE · 2020 to 2020
$225k
NHLBI NIH HHS R01 HL158519NIAID NIH HHS R41 AI149789NIGMS NIH HHS R01 GM066189
6 · The paper itself

Abstract

Sepsis is characterized by profound immunometabolic dysregulation, yet the role of purine precursor synthesis in immune reprogramming remains poorly defined. Intracellular purine nucleotides, such as ATP, are generated by

Identifiers

PMID41756441
PMCPMC12935003

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.